Medical Image of the Week: Atherosclerotic Aneurysm of Aortic Arch and Descending Thoracic Aorta

Figure 1.  Chest radiograph displays mild CHF, prominent vascular markings, and a large thoracic aneurysm.

Figure 2. Panel A: Computerized tomography angiography (CTA) with contrast displays an aneurysm of the aortic measuring 6.8 cm with eccentric thrombi. Panel B: CTA also shows an aneurysm of the descending aorta measuring 6 cm across with eccentric thrombi. Panel C: CTA demonstrates a tortuous descending aorta displayed by the curving of the descending aorta as it transitions to the abdominal aorta.

A 94-year-old Spanish-speaking woman presented to the hospital with intermittent episodes of dyspnea and abdominal pain for one week. Her past medical history was notable for 30 pack-year smoking history and hypertension, which was reportedly controlled with medical therapy.  Physical exam showed trace peripheral edema bilaterally, intact peripheral pulses, and a mild abdominal bruit. Work up at the emergency department revealed a non-ST elevation myocardial infarction with troponin T of 0.34 ng/mL but no ST-wave abnormality on electrocardiography. Chest x-ray displayed an incidental thoracic aneurysm (Figure 1). Chest computed tomography with contrast demonstrated a continuous aneurysm of the aortic arch and descending thoracic aorta with diameters measuring 6.8 cm and 6 cm, respectively (Figure 2A and 2B). Eccentric thrombi are noted in the aortic arch and the descending aorta. Interestingly, the distal descending thoracic aorta curves as it transitions to the abdominal aorta, which is evidence of a tortuous descending aorta (Figure 2C). The patient declined both invasive and non-invasive treatment and left the hospital against medical advice one day after admission.     

Melvin Parasram MS¹, Lea McKinnon MD², Iwan Nyotowidjojo MD³, and Kareem Ahmad MD⁴

¹Midwestern University: Arizona College of Osteopathic Medicine, Glendale, AZ USA

²Departments of Radiology, ³Internal Medicine and ⁴Pulmonary and Critical Care, Banner University Medical Center - Tucson, Tucson, AZ USA

Cite as: Parasram M, McKinnon L, Nyotowidjojo I, Ahmad K. Medical image of the week: atherosclerotic aneurysm of aortic arch and descending thoracic aorta. Southwest J Pulm Crit Care. 2016;12(2):46-7. doi: http://dx.doi.org/10.13175/swjpcc155-15 PDF 

Medical Image of the Week: Remote Calvarial Renal Cell Metastases

Figure 1. Contrast enhanced axial MRI image shows the metastatic lesion in the right skull with mass effect and midline shift.

Figure 2. Coronal Image shows the extensive calvarial metastatic lesion and its mass effect.

A 57-year-old woman with past medical history significant for clear cell renal carcinoma and radical nephrectomy 9 years prior was admitted to our hospital for headache and left hemiparesis with associated numbness. Symptoms were progressive and had begun about 5 days prior to her presenting to our emergency department. Neurologic exam was significant for reduced strength in her left upper and lower extremities as well as well as sensory deficit to fine touch and vibratory sensation in her left arm. Her gait was unsteady and she was unable to ambulate without assistance. Her right calvarium was grossly enlarged and asymmetrical with softening of the underlying boney structures. 

MRI of the brain showed a 10 cm x 5 cm mass that was obliterating the calvarium and invading the dura mater (Figure 1).  There was mass effect with shift of the midline structures from right to left by approximately 6.5 mm (Figures 1 and 2). This was biopsy proven to be metastatic renal cell carcinoma. Additional smaller calvarium lesions were also seen. At least 3 and possibly 4 parenchymal metastatic deposits are seen in the left occipital lobe. Renal cell carcinoma has been well described to recur after long periods of remission, up to 33 years (1).

She was initially treated with intravenous dexamethasone with resolution of symptoms after 48 hours. Palliative radiation is being provided at this time.

Anthony Witten MD, Hem Desai MD, Ryan Wong MD and Joao Ferreira MD

Department of Internal Medicine

University of Arizona College of Medicine

Tucson, AZ USA

Reference

1. Parada SA, Franklin JM, Uribe PS, Manoso MW. Renal cell carcinoma metastases to bone after a 33-year remission. Orthopedics. 2009 Jun;32(6):446. [CrossRef] [PubMed]

Cite as: Witten A, Desai H, Wong R, Ferreira J. Medical image of the week: calvairial renal cell metastases. Southwest J Pulm Crit Care. 2016;12(1):32-3. doi: http://dx.doi.org/10.13175/swjpcc154-15 PDF

Medical Image of the Week: Coffee Bean and Whirlpool Signs

Figure 1. Supine abdominal x-ray demonstrating a large dilated loop of bowel and coffee bean sign (red circle).

Figure 2. Contrast CT abdomen (coronal section) showing markedly dilated sigmoid loop with the swirling mesentery (whirlpool sign) (red circle).

A 79-year-old woman with a history of Parkinson’s disease presented with altered mental status, poor oral intake, and multiple episodes of nausea and vomiting. An abdominal x-ray demonstrated dilated loops of bowel and the coffee bean sign concerning for sigmoid volvulus (Figure 1). The coffee bean sign occurs when a thick “inner wall” represents the double wall thickness of opposed loops of bowel while the thinner outer walls due single thickness. A contrast CT abdomen showed dilated sigmoid loop and whirlpool sign confirming sigmoid volvulus (Figure 2). She underwent a total colectomy with ileorectal anastomosis and full recovery.

Brittany Bartolome MS3¹, Choua Thao MD², Yaser Dawod MD², and Carmen Luraschi MD³

¹University of Nevada School of Medicine, Reno, NV USA

²Department of Internal Medicine, University of Nevada School of Medicine, Las Vegas, NV USA

³Division of Pulmonary and Critical Care, University of Nevada School of Medicine, Las Vegas, NV USA

Cite as: Bartolome B, Thao C, Dawod Y, Luraschi C. Medical image of the week: coffee bean and whirlpool signs. Southwest J Pulm Crit Care. 2016;12(1):30-1. doi: http://dx.doi.org/10.13175/swjpcc002-16 PDF

Medical Image of the Week: Mediastinal Metastases Causing Right Ventricular Outflow Obstruction

Figure 1. Computed tomography (CT) of chest showed large right mediastinal mass (arrow) causing mass effect on the heart.

Figure 2.  Echocardiography showing large extra-cardiac mass (white arrow) compressing on right ventricle and its outflow tract (black arrow).

A 36-year-old man with a history of testicular choriocarcinoma with metastases to the lung presented with a 2-days history of hemoptysis. Initial diagnosis of the malignancy was made about 5 months earlier and he was treated with platinum based chemotherapy with a partial response.

He reported two days of significant hemoptysis, associated with shortness of breath and pleuritic chest pain and rapidly developed acute hypoxic respiratory failure requiring emergent intubation and mechanical ventilation. Computed tomography (CT) of chest showed large right mediastinal mass with diffuse reticular and nodular opacities predominantly in the left lung (Figure 1).

A pulmonary angiogram was performed that showed multiple active bleeding sites in the bronchial arterial system. These were treated with embolization. He developed shock and during investigations the echocardiogram showed a significant compression of the superior vena cava, right atrium and right ventricle by the malignant mass (Figure 2). Despite aggressive therapy and resuscitative therapies he continued to deteriorate and did not survive the hospital stay.

Mediastinal tumors are a rare cause of extrinsic right ventricular outflow tract (RVOT) obstruction. Echocardiography is an important tool in the assessment of hemodynamic effects caused due to such pathology including degree of compression and pressure gradients.

Kai Rou Tey MD¹, Bhupinder Natt MD²

¹Department of Internal Medicine, University of Arizona College of Medicine- South Campus, Tucson, AZ USA

²Division of Pulmonary, Critical Care, Allergy and Sleep, University of Arizona Medical Center, Tucson, AZ USA

Cite as: Tey KR, Natt B. Medical image of the week: mediastinal metastases causing right ventricular outflow obstruction. Southwest J Pulm Crit Care. 2016:12(1):22-3. doi: http://dx.doi.org/10.13175/swjpcc145-15 PDF

Medical Image of the Week: Phytobezoar

Figure 1. Supine portable abdominal radiograph. Note the massively distended stomach, outlined by the arrows, with an internal mottled appearance. There is inferior displacement of the transverse colon (arrowhead) contouring to the greater curvature of the stomach.

A 10-year-old boy with a history of non-verbal autism presented to the hospital with symptoms of chronic malnourishment. He was recently started on a specific carbohydrate rich diet, as outlined by a popular mainstream nutrition book, with hopes of improvement in adverse behavior. Prior to the start of this new diet, he consistently demonstrated an increased craving for food and was described to have an insatiable appetite. Though he was relatively non-verbal at baseline, he intermittently voiced his hunger and associated abdominal pain.

A supine abdominal radiograph obtained immediately after admission showed a moderate gastric distension with a significant stool burden. Follow-up radiographs of the abdomen were obtained after two days of medical attempts to clear out the gastrointestinal system. The supine frontal radiograph at this time showed a massively distended stomach with a mottled appearance and considerable mass effect on the transverse colon (Figure 1). The interpreting pediatric radiologist immediately raised a diagnosis of gastric bezoar, which was later confirmed intra-operatively. Initially, an endoscopic approach was tried in an attempt to evacuate the stomach. However, considering the tremendous compaction of the phytobezoar, laparotomy was performed. After confirmation of normal gastric anatomy, several liters of vegetable material were removed from the stomach, and the gastrotomy was closed.

Gastric bezoar is defined as a gastric foreign body resulting from accumulation of ingested material, often found as a hard mass or concretions within the stomach (1). Bezoars are classified according to the contents; phytobezoars contain vegetable materials, whereas trichobezoars contains hair (2). Bezoars usually form in the stomach and can pass into the small bowel where they occasionally cause obstruction. Characteristic radiographic findings can point to the diagnosis of bezoar on plain film radiographs while barium studies are often confirmatory. Many interventions have been described for the treatment of phytobezoars from carbonated nasogastric lavages to endoscopic retrieval (3).  However, in severe cases, a surgical approach is necessary in order to prevent further complications.

Amrit Hansra, MD and Unni Udayasankar, MD

Department of Medical Imaging

University of Arizona

Tucson, AZ USA

References

1. Kadian RS, Rose JF, Mann NS. Gastric bezoars--spontaneous resolution. Am J Gastroenterol. 1978;70:79-82. [PubMed]
2. Lee J. Bezoars and foreign bodies of the stomach. Gastrointest Endosc Clin N Am. 1996;6:605-19. [PubMed]
3. Song KY, Choi BJ, Kim SN, Park CH. Laparoscopic removal of gastric bezoar. Surg Laparosc Endosc Percutan Tech. 2007;17:42-4. [CrossRef] [PubMed]

Cite as: Hansra A, Udayasankar U. Medical image of the week: phytobezoar. Southwest J Pulm Crit Care. 2016;12(1):20-1. doi: http://dx.doi.org/10.13175/swjpcc142-15 PDF

January 2016 Imaging Case of the Month

Michael B. Gotway, MD 

Department of Radiology

Mayo Clinic Arizona

Scottsdale, AZ

Imaging Case of the Month CME Information  

Members of the Arizona, New Mexico, Colorado and California Thoracic Societies and the Mayo Clinic are able to receive  0.25 AMA PRA Category 1 Credits™. Completion of an evaluation form is required to receive credit and a link is provided on the last panel of the activity.

0.25 AMA PRA Category 1 Credit(s)™

Estimated time to complete this activity: 0.25 hours

Lead Author(s): Michael B. Gotway, MD. All Faculty, CME Planning Committee Members, and the CME Office Reviewers have disclosed that they do not have any relevant financial relationships with commercial interests that would constitute a conflict of interest concerning this CME activity. 

Learning Objectives:
As a result of this activity I will be better able to:    

1. Correctly interpret and identify clinical practices supported by the highest quality available evidence.
2. Will be better able to establsh the optimal evaluation leading to a correct diagnosis for patients with pulmonary, critical care and sleep disorders.
3. Will improve the translation of the most current clinical information into the delivery of high quality care for patients.
4. Will integrate new treatment options in discussing available treatment alternatives for patients with pulmonary, critical care and sleep related disorders.

Learning Format: Case-based, interactive online course, including mandatory assessment questions (number of questions varies by case). Please also read the Technical Requirements.

CME Sponsor: University of Arizona College of Medicine at the Arizona Health Sciences Center.

Current Approval Period: January 1, 2015-December 31, 2016

Financial Support Received: None.

Clinical History: A 44 year-old man presented with refractory heart failure following the relatively asymptomatic detection of severe aortic regurgitation at auscultation 11 years earlier. When the valvular disease was discovered, the patient’s left ventricular ejection fraction was 25%. He underwent open aortic valvular replacement and his systolic function stabilized on medication in the years that followed, but eventually his cardiac function deteriorated further and he was listed for cardiac transplant.

As part of the pre – transplant evaluation frontal and lateral chest radiography (Figure 1) was performed.

Figure 1. Frontal (A) and lateral (B) chest radiography. 

Which of the following statements regarding the chest radiograph is most accurate? (Click on the correct answer to proceed to the second of six panels)

1. The frontal chest radiograph shows a relatively circumscribed opacity at the left base
2. The frontal chest radiograph shows abnormal mediastinal contours
3. The frontal chest radiograph shows basal predominant fibrotic abnormalities
4. The frontal chest radiograph shows large lung volumes with a cystic appearance
5. The frontal chest radiograph shows no abnormal findings

Cite as: Gotway MB. January 2016 imaging case of the month. Southwest J Pulm Crit Care. 2016;12(1):13-9. doi: http://dx.doi.org/10.13175/swjpcc001-16 PDF

Medical Image of the Week: Prozac Eyes

Figure 1. 60-second epoch shows the slow rolling eye movements (red arrow) and rapid eye movements (green arrows) seen during NREM stage 2 sleep.

A 59-year-old man with a past medical history significant for hypertension, obesity and depression underwent an overnight polysomnogram for high clinical suspicion for obstructive sleep apnea. His current medications include doxepin, fluoxetine, bupropion, ambien and amlodipine. A snapshot during NREM sleep is shown (Figure 1).

Fluoxetine (Prozac®) is a potent selective serotonin reuptake inhibitor (SSRI).“Omnipause” neurons in the brainstem inhibit saccadic eye movements. NREM eye movements result from the potentiation of serotonergic neurons that inhibit these neurons (1). These eye movements occur during all stages of NREM sleep. These atypical eye movements have been reported to be present with a lower incidence with use of other antidepressants, benzodiazepines and neuroleptics and they tend to persist even after discontinuation of the medication (2). The clinical significance of these eye movements is unknown.

Safal Shetty MD, Sarah Patel MD, Kenneth S. Knox MD

Section of Pulmonary, Allergy, Critical Care & Sleep Medicine

Banner University Medical Center

Tucson, AZ USA

References

1. Schenck CH, Mahowald MW, Kim SW, O'Connor KA, Hurwitz TD.Prominent eye movements during NREM sleep and REM sleep behavior disorder associated with fluoxetine treatment of depression and obsessive-compulsive disorder. Sleep. 1992;15(3):226-35. [PubMed]
2. Geyer JD, Carney PR, Dillard SC, Davis L, Ward LC. Antidepressant medications, neuroleptics, and prominent eye movements during NREM sleep. J Clin Neurophysiol. 2009;26(1):39-44. [CrossRef] [PubMed] 

Cite as: Shetty S, Patel S, Knox KS. Medical image of the week: prozac eyes. Southwest J Pulm Crit Care. 2015;11(6):284. doi: http://dx.doi.org/10.13175/swjpcc128-15 PDF

Medical Image of the Week: Alpha Intrusion into REM Sleep

Figure 1. 30-second epoch during NREM sleep (Stage N3). The red arrows show alpha waves (8-12 Hz frequency) on delta waves (0.5-2 Hz), most prominently seen in the frontal and central EEG leads.

Figure 2. 30 second epoch during REM sleep showing bursts of alpha activity during REM sleep (red arrow) with hypersynchronous theta wave activity (4-7 Hz) (blue arrow).

A 45-year-old woman with a past medical history of hypertension and chronic headaches was referred to the sleep laboratory for high clinical suspicion for sleep apnea based on a history of snoring, witnessed apnea and excessive daytime sleepiness. An overnight sleep study was performed. Images during N3 Sleep and REM sleep are shown (Figures 1 and 2).

Alpha intrusion in delta sleep is seen in patients with fibromyalgia, depression, chronic fatigue syndrome, anxiety disorder, and primary sleep disorders like psychophysiological insomnia, obstructive sleep apnea, circadian disorders and narcolepsy (1).

Bursts of alpha waves during REM sleep may be more common during phasic REM than tonic REM. The REM alpha bursts (alpha activity lasting at least 3 seconds without an increase in EMG amplitude) may represent microarousals (2).  

Hypersynchronous theta activity should be differentiated from the spike and waveform activity seen in seizures.

Safal Shetty MD, Tam Le, MD

Banner University Medical Center

Tucson, AZ

References

1. Jaimchariyatam N, Rodriguez CL, Budur K. Prevalence and correlates of alpha-delta sleep in major depressive disorders. Innov Clin Neurosci. 2011;8(7):35-49. [PubMed]
2. Cantero JL, Atienza M. Alpha burst activity during human REM sleep: descriptive study and functional hypotheses. Clin Neurophysiol. 2000;111(5):909-15. [CrossRef] [PubMed] 

Cite as: Shetty S, Le T. Medical image of the week: alpha intrusion into REM sleep. Southwest J Pulm Crit Care. 2015;11(6):273-4. doi: http://dx.doi.org/10.13175/swjpcc126-15 PDF

Medical Image of the Week: Empyema Necessitans

Figure 1. Panel A: chest radiograph on admission showed mass like lesion centered at the right upper lobe. Panel B: Coronal CT cut showing loculated fluid collection demonstrating peripheral rim enhancement. There is extension of pleural fluid into the soft tissues of the adjacent right chest wall (white arrow).

Figure 2. Panel A: chest radiograph after VATS decortication and antibiotic course shows resolution. Panel B: axial CT cut after completion of therapy shows complete resolution.

A previously healthy 46-year-woman was evaluated for two week history of right shoulder pain, associated pleuritic chest pain and dyspnea.

Chest radiograph showed right apical mass (Figure 1A). Imaging  showed loculated fluid collection with extension into the soft tissues of the adjacent right chest wall suggestive of empyema necessitans (Figure 1B).

Chest Tube placement was done along with broad spectrum antibiotics. Blood and pleural fluid cultures showed methicillin-resistant Staphylococcus aureus (MRSA). Due to persistence of loculation despite antibiotics, she underwent a video-assisted-thoracoscopic surgery (VATS) for decortication and further drainage of the effusion.

Symptoms and radiologic findings improved and she was discharged with intravenous antibiotics to complete a six week course. Chest imaging at six week period showed complete resolution (Figure 2).

Empyema necessitans, defined by the extension of an empyema through the parietal pleura, into surrounding tissue is becoming rare with the routine drainage of empyema and antibiotics use. Common causative pathogens include Mycobacterium tuberculosis, Actinomyces israelii, Streptococcus pneumoniae, and Staphylococcus aureus (1). Surgical treatments for thoracic empyema include chest tube drainage, debridement via VATS, decortication, open window thoracostomy, and thoracoplasty (2).

Kai Rou Tey MD¹, Bhupinder Natt MD²

¹Department of Internal Medicine - South Campus and ²Department of Pulmonary, Critical Care, Allergy and Sleep

University of Arizona College of Medicine

Tucson, AZ USA

References

1. Kono SA, Nauser TD. Contemporary empyema necessitatis. Am J Med. 2007;120(4):303-5. [CrossRef] [PubMed]
2. Molnar TF. Current surgical treatment of thoracic empyema in adults. Eur J Cardiothorac Surg. 2007;32(3):422-30. [CrossRef] [PubMed] 

Cite as: Tey KR, Natt B. Medical image of the week: empyema necessitans. Southwest J Pulm Crit Care. 2015;11(6):271-2. doi: http://dx.doi.org/10.13175/swjpcc139-15 PDF 

Medical Image of the Week: Diffuse Axonal Injury

Figure 1. Panel A: Non-contrast CT of the head demonstrating hyperdense foci at the gray-white junction of the cortex and subcortical white matter (red arrows). Panel B: Hyperdense focus in the pons (red arrow).

Figure 2. MRI of the brain with a gradient recall echo (GRE) sequence demonstrating more pronounced hypointense foci consistent with hemorrhage.

An 18-year-old man without any significant past medical history presented to the emergency room trauma bay as an unrestrained passenger involved in a head-on collision at 85 mph. In the emergency room, he was found to have a GCS of 6 and was intubated for airway protection. A non-contrast CT of the head demonstrated hyperdense foci in the frontal lobes at the gray-white junction (Figure 1A) and a hyperdense focus in the pons (Figure 1B) consistent with punctate hemorrhages. An MRI of the brain with a gradient recall echo (GRE) sequence (Figure 2) demonstrated more pronounced hypointense foci consisent with hemorrhage. In the setting of the patient’s deceleration injury, the summation of his clinical and imaging findings was consistent with diffuse axonal injury.

Diffuse axonal injury (DAI) is pattern of closed head injury that results in a traumatic shear injury to the neuronal axons secondary to sudden deceleration and change in angular momentum. This pattern of injury often occurs at the interface between tissues of differing density such as the gray-white junction of the cerebral cortex and subcortical white matter. DAI can also be seen in deeper portions of the brain, such as the corpus callosum and brainstem, that are relatively fixed compared with more superficial portions of the brain resulting in greater rotational/ shear stress forces focused in these locations during sudden deceleration. Visible lesions on CT often underestimate the extent of neuronal injury (often described as the “tip of iceberg”), and neuronal injury is better delineated on MRI.

Most patients present with an immediate coma necessitating intubation for airway protection.  In mild cases, patients often experience mild traumatic brain injury characterized by heachaces, mild cognitive impairment, and personality changes. In more severe cases, DAI can result in a persistent vegetative state. Treatment is supportive in all cases.

Jack Hannallah, MD¹; Tammer Elaini, MD²; Kelly Wickstrom, DO³; Rorak Hooten, MD³; Michael Habib, MD²

Departments of ¹Surgery,²Pulmonary/Critical Care, and ³Internal Medicine

University of Arizona

Tucson, AZ USA

References

1. Yanagawa Y, Sakamoto T, Takasu A, Okada Y. Relationship between maximum intracranial pressure and traumatic lesions detected by T2*-weighted imaging in diffuse axonal injury. J Trauma. 2009;66(1):162-5. [CrossRef] [PubMed] 
2. Tong KA, Ashwal S, Holshouser BA, Shutter LA, Herigault G, Haacke EM, Kido DK. Hemorrhagic shearing lesions in children and adolescents with posttraumatic diffuse axonal injury: improved detection and initial results. Radiology. 2003;227(2):332-9. [CrossRef] [PubMed] 

Cite as: Hannallah J, Elaini T, Wickstrom K, Hooten R, Habib M. Medical image of the week: diffuse axonal injury. Southwest J Pulm Crit Care. 2015;11(6):264-5. doi: http://dx.doi.org/10.13175/swjpcc121-15 PDF

December 2015 Imaging Case of the Month

Michael B. Gotway, MD 

Department of Radiology

Mayo Clinic Arizona

Scottsdale, AZ

Clinical History: An 80-year-old woman with a history of polycythemia vera (12 years), migraines, hypertension, and gastroesophageal reflux disease presented with complaints of declining functional status due to worsening shortness of breath over 3-4 weeks’ duration. She also complained of occasional palpitations. No history of fever, cough, chest pain, or hemoptysis was elicited. A frontal chest radiograph (Figure 1) was performed.

Figure 1.  Panel A: Frontal chest radiograph obtained at presentation, when the patient complained of worsening shortness of breath. Panel B: 3 years earlier.

Which of the following statements regarding the chest radiograph is most accurate? (Click on the correct answer to proceed to the second of five panels)

1. The frontal chest radiograph shows abnormal mediastinal contours
2. The frontal chest radiograph shows fairly diffuse, bilateral, increased opacity
3. The frontal chest radiograph shows layering pleural effusions bilaterally
4. The frontal chest radiograph shows multifocal consolidation
5. The frontal chest radiograph shows no abnormal findings

Cite as: Gotway MB. December 2015 imaging case of the month. Southwest J Pulm Crit Care. 2015;11(6):254-9. doi: http://dx.doi.org/10.13175/swjpcc150-15 PDF 

Medical Image of the Week: Pulmonary Thomboembolism Complicated by Free Floating Atrial Thrombus

Figure 1. Thoracic CT angiogram showing filling defects in the right pulmonary arterial system (arrows).

 

Figure 2. Thoracic CT angiogram showing filling defects in the left pulmonary arterial system (arrow).

 

Figure 3. Video of transthoracic echocardiogram showing thrombus in the right atrium.

An 82-year-old female presented to the emergency department four days after suffering a fall at home. She complained of left hip pain, weakness and shortness of breath. Physical exam demonstrated a blood pressure of 82/60 mm Hg, pulse of 120 bpm, and room air oxygen saturation measured by pulse oximetry of 81%. Exam was otherwise remarkable for pain on movement of the left hip. Laboratory exam was remarkable for troponin of 2.5 ng/ml and pro-beta natiuretic peptide of 31,350 pg/ml. Chest radiograph demonstrated elevation of the right hemidiaphragm. EKG demonstrated sinus tachycardia with a rightward axis and an interventricular conduction defect. Left hip film disclosed a non-displaced femoral neck fracture. CAT-angiography of the chest revealed pulmonary emboli involving all five lobes with significant bilateral proximal pulmonary arterial filling defects (Figures 1,2). Venous Doppler examination demonstrated left lower extremity deep vein thrombosis. Trans-thoracic echocardiogram demonstrated right ventricular enlargement and a large unattached, right atrial thrombus (Figure 3). The patient was treated with 100 mg of tissue plasminogen activator (tPA) administered over 2 hours, followed by intravenous unfractionated heparin, with subsequent improvement of both her hemodynamic and oxygenation status. A repeat echocardiogram 48 hours after the administration of tPA demonstrated complete resolution of the right atrial clot. The patient has continued to do well.

Discussion

Free floating right heart thrombi (FFRHT), also known as “emboli in transit”, are mobile, unattached masses, and may be present in up to 18% of patients with pulmonary emboli (1). Untreated, the mortality of FFRHT approaches 100%. Therapeutic options include anticoagulation (28.6% mortality), surgical embolectomy (23.8% mortality), and thrombolysis (11.3% mortality, survival benefit (p<0.05) )(2). There are case reports of percutaneous catheter directed therapies, with varying degrees of success described (1,3). Floating right heart thrombi represent a severe subset of pulmonary thromboembolic disease and warrant immediate intervention. Although therapy must be individualized, thrombolysis appears to offer improved survival when compared to anticoagulation or surgical embolectomy.

Charles J. VanHook, Douglas Tangel, James Jonas

Department of Intensive Care Medicine

Longmont United Hospital

Longmont, CO USA

References

1. Chartier L, Bera J, Delomez M, Asseman P, Beregi JP, Bauchart JJ, Waremburg H, Thery C. Free-floating thrombi in the right heart. Circulation. 1999;99:2779-83. [CrossRef] [PubMed]
2. Rose PS, Punjabi NM, Pearse DB. Treatment of right heart pulmonary emboli. Chest. 2002;121(3):806-14. [CrossRef] [PubMed]
3. Maron B, Goldhaber SZ, Sturzu AC, Rhee DK, Ali B, Pinak BS, Kirshenbaum JM. Cather-directed thomobolysis for giant right atrial thrombus. Circulation:Cardiovascular Imaging 2010;3:126-7. [CrossRef] [PubMed]

Cite as: VanHook CJ, Tangel D, Jonas J. Medical image of the week: pulmonary thromboembolism complicated by free floating atrial thrombus. Southwest J Pulm Crit Care. 2015;11(6):252-3. doi: http://dx.doi.org/10.13175/swjpcc119-15 PDF

Medical Image of the Week: Virtual Anatomical Dissociation During Electromagnetic Navigation Bronchoscopy

Figure 1. During the first navigation virtual bronchoscope image and 3D map (top left and bottom left) show the tip of the locatable guide in the posterior segment of the right upper lobe matching live video bronchoscope image.

Figure 2. Second navigation: the virtual bronchoscope image and 3D map (top left and bottom left) show the tip of the bronchoscope in the right main bronchus whereas the video bronchoscope shows the tip in the posterior segment of the right upper lobe.

A 59 year-old woman with a 40 pack-year smoking history was referred to our practice with a 2.5 cm spiculated right upper lobe lung nodule for a diagnostic bronchoscopy.

We performed electromagnetic navigation bronchoscopy under general anesthesia in the operating room. After successfully navigating to the lesion and obtaining 3 needle biopsy samples and two cytology brush samples we lost target alignment. After attempting to rotate and reposition the catheter several times it was decided to re-navigate from the trachea. Two images comparing virtual navigation to real anatomy during the first and second navigation attempts are provided bellow (Figures 1 and 2).

Why are the virtual images different? (Click on the correct answer for a discussion)

1. It is an artifact from respiratory movements
2. The locatable guide is outside the sensing volume
3. You should suspect a pneumothorax
4. Your registration procedure was suboptimal, you should repeat it.

Cite as: Vazquez-Guillamet R, Horn E, Sarver R, Melendres L. Medical image of the week: virtual anatomical dissociation during electromagnetic navigation bronchoscopy. Southwest J Pulm Crit Care. 2015;11(5):238-9. doi: http://dx.doi.org/10.13175/swjpcc111-15 PDF

Medical Image of the Week: Atherosclerotic Aneurysm of Great Vessels

Figure 1.Unsual appearance of the aortic root with irregular contours and a 41 x 37mm dilatation at the level of the sinuses of Valsalva.

Figure 2. Saccular outpouchings of the intrathoracic great vessels.

Figure 3. Video of the MRI images of the intrathoracic vascular abnormalities.

A 60 year-old man with a 33 pack-year history of tobacco abuse, presented with difficulty speaking and voice change for several weeks. His review of systems was positive for fatigue, night sweats and weight loss. Physical exam of the oropharynx with flexible laryngoscopy demonstrated immobile bilateral true and false vocal cords fixed in the para-median position without laryngeal lesions. Concern for intra-thoracic process with recurrent laryngeal nerve involvement, a computed tomography (CT) of the chest and thoracic vessels demonstrated unusual appearing arteries with multiple penetrating atherosclerotic ulcers versus saccular aneurysms scattered throughout the aorta and its major branches (Figures 1 and 2). A magnetic resonance imaging (MRI) with contrast, demonstrated multiple foci of saccular outpouchings involving the arch vessels distal to their origins with the largest dilatation measuring 26 x 25 mm in the case of proximal innominate (Figure 3). Although imaging lacked resolution, it was specialist opinion that patient likely had compression of recurrent laryngeal nerve leading to vocal cord dysfunction without significant airway compromise.

Atherosclerotic aneurysms of the great vessels are rare with evidence limited to case series (1,2). Patient presentation varies dependent on the structures involved including embolic phenomenon from atherosclerosis. Surgical intervention with endovascular approach remains treatment of choice with good success rate.

Given our patient’s poor nutritional status, multiple co-morbidities and diagnosis of large colonic mass, risks of surgery outweighed benefits of intervention and thus outpatient follow up was recommended.

Faraz Jaffer, MD and Don Leo Pepito, MD

Department of Internal Medicine

Banner-University Medical Center – South

Tucson, AZ

References

1. Cury M, Greenberg RK, Morales JP, Mohabbat W, Hernandez AV. Supra-aortic vessels aneurysms: diagnosis and prompt intervention. J Vasc Surg. 2009;49(1):4-10. [CrossRef] [PubMed]
2. Kasashima F, Urayama H, Ohtake H, Watanabe Y.Intrathoracic aneurysm of the innominate and right subclavian arteries: report of a case. Surg Today. 2001;31(1):51-4. [CrossRef] [PubMed] 

Cite as: Jaffer F, Pepito DL. Medical image of the week: athersclerotic aneurysm of great vessels. Southwest J Pulm Crit Care. 2015;11(5):231-2. doi: http://dx.doi.org/10.13175/swjpcc104-15 PDF 

Medical Image of the Week: Cutaneous Coccidioidomycosis

Figure 1. Right distal anterior thigh. Fungal culture grew Coccidioides immitis from biopsy.

A 46-year-old Hispanic man with no known past medical history presents to his primary care physician for a progressively worsening “rash” located over his right thigh. Patient described the lesion as raised, scaly, and itchy. It has been “growing” for the past one year and started out as a small “pimple”. Patient denied any trauma to the effected region over this time period. Surgical history was significant for a splenectomy 15 years prior that was needed after a traumatic accident. He works in construction and lives in southern Arizona. He denied alcohol, tobacco and or illicit drug use. Patient has attempted to treat this skin lesion with over the counter hydrocortisone ointment with no relief. He denied any other associated symptoms including fever/chills, headache, vision changes, night sweats, weight loss, cough, shortness of breath, and or joint pains. Vital signs were stable upon presentation. Physical exam was entirely benign other than the isolated skin lesion shown above (Figure 1). It measured roughly 5cm at its greatest dimension and was located just superior the right knee on the anterior portion of the distal thigh. Nodularity was appreciated upon palpation but no tenderness was noted. Areas of erythema were non-blanching. Small satellite lesions were seen on the perimeter.

He was sent to a dermatologist and biopsies were performed. Light microscopy and culture confirmed the diagnosis of cutaneous coccidioidomycosis. Initial laboratory work revealed a normal complete blood count and complete metabolic panel. Serum coccidioides IgM antibody was negative but IgG was confirmed to be positive with a reflex complement fixation titer of 1:16. Chest X-ray was normal. Patient was started on oral fluconazole 400mg daily. Repeat coccidioides IgG titers decreased to 1:8 at a four- week follow-up. Patient has been tolerating the medication well and skin lesion has begun to regress.

Norman Beatty MD¹ and Mayar Al Mohajer MD²

¹Departments of Internal Medicine and ²Infectious Diseases

University of Arizona College of Medicine

Tucson, AZ

Cite as: Beatty N, Al Mohajer M. Medical image of the week: cutaenous coccidioidomycosis. Southwest J Pulm Crit Care. 2015;11(5):226-7. doi: http://dx.doi.org/10.13175/swjpcc110-15 PDF

November 2015 Imaging Case of the Month

Michael B. Gotway, MD 

Department of Radiology

Mayo Clinic Arizona

Scottsdale, AZ

Clinical History: A 48-year-old non-smoking woman with a history of hysterectomy and right oophorectomy, and cholecystectomy, otherwise previously healthy, presented with right-sided chest pain. A frontal chest radiograph (Figure 1) was performed.

Figure 1. Frontal chest radiograph.

Which of the following statements regarding the chest radiograph is most accurate? (Click on the correct answer to proceed to the second of eight panels)

1. The frontal chest radiograph shows a right-sided pneumothorax
2. The frontal chest radiograph shows abnormal mediastinal contours
3. The frontal chest radiograph shows bilateral pleural thickening
4. The frontal chest radiograph shows no abnormal findings
5. The frontal chest radiograph shows small lung volumes with multiple small nodules

Cite as: Gotway MB. November 2015 imaging case of the month. Southwest J Pulm Crit Care. 2015;11(5):218-25. doi: http://dx.doi.org/10.13175/swjpcc140-15 PDF

Medial Image of the Week: Palmar Erythema Multiforme

Figure 1. Palmar rash in a patient with acute pulmonary coccidioidomycosis resembling erythema multiforme.

An 18 year-old male presented for evaluation of abnormal chest imaging. Prior to moving to Tucson, Arizona three weeks before presentation, he was diagnosed with ankylosing spondylitis and was started on adalimumab (Humira). Approximately one week prior to presentation he developed a fever and cough. Over 3-4 days the cough worsened and he developed a palmar rash (Figure 1). He was seen in the emergency department and was started on levofloxacin. Prior to presentation in the pulmonary clinic his rash had resolved but the cough had persisted. Chest imaging showed airspace opacities within the left upper lobe with associated small left pleural effusion. Bronchoalveolar lavage revealed 57% eosinophils. Fungal cultures, bacterial cultures, and cytology were non-diagnostic. Coccidioides IgG antibody was negative but Coccidioides IgM antibody converted to positive, suggesting acute infection. The patient was started on oral fluconazole and clinically improved. Erythema nodosum and erythema multiforme are noted in as many as 25 % of patients with acute pulmonary coccidioidomycosis. The rashes usually occur within a few days of infection and are considered a good prognostic sign (1).

Ryan Nahapetian, MD, MPH and Joshua Malo, MD

Pulmonary, Allergy, Critical Care, & Sleep Medicine

University of Arizona, Tucson, AZ

Reference

1. Smith JA, Riddell J 4th, Kauffman CA. Cutaneous manifestations of endemic mycoses. Curr Infect Dis Rep. 2013;15(5):440-9. [CrossRef] [PubMed]

Cite as: Nahapetian R, Malo J. Medical image of the week: palmar erythema multiforme. Southwest J Pulm Crit Care. 2015;11(5):217. doi: http://dx.doi.org/10.13175/swjpcc102-15 PDF

Medical Image of the Week: 'CSFoma'

Figure 1. Chest X-ray showing the ‘CSFoma’ in the right pleural space. The shunt can be traced to the lesion. Also seen is a right-sided peripherally inserted central catheter (PICC) line.

A 34 year old woman with a history of CNS coccidiodomycosis leading to hydrocephalus treated with a ventriculo-peritoneal (V-P) shunt along with antifungal treatment was admitted for a post abdominal surgery wound infection. The V-P shunt was revised due to concerns of infection to a ventriculo-pleural shunt. This lead to a collection of cerebrospinal fluid (CSF) in the pleural cavity in a loculated fashion appearing as a pleural ‘CSFoma’.

V-P shunts are placed to drain excessive CSF which otherwise can lead to hydrocephalus and increased intracrnaial pressures. ‘CSFoma’ is a pseudocyst usually seen in the abdomen since most ventricular drains are placed in the peritoneal cavity. Adhesions, blockages or inadequate absorption can lead to collection of the CSF at the distal end of the catheter. These usually self resolve by reabsorption or can be treated by repositioning the catheter or draining the fluid percutaneuosly.

Our patient had a self resolution once the VP drain was repositioned to the peritoneal cavity after the infection was treated.

Sohail Habibi MD¹, Craig Jenkins DO¹ and Bhupinder Natt MD²

¹Department of Internal Medicine

²Division of Pulmonary, Critical Care, Allergy and Sleep Medicine

Banner-University Medical Center

Tucson, AZ

Cite as: Habibi S, Jenkins C, Natt B. Medical image of the week: 'CSFoma'. Southwest J Pulm Crit Care. 2015;11(4):192. doi: http://dx.doi.org/10.13175/swjpcc101-15 PDF

Medical Image of the Week: Acute Amiodarone Pulmonary Toxicity

Figure 1. Chest X-ray showing diffuse interstitial markings, right upper lobe consolidation, small pleural effusions, thoracotomy wires and external leads.

Figure 2. Axial image of the thoracic CT scan showing increased interstitial markings, ground glass opacities and bilateral pleural effusions.

A 71 year old man with a medical history significant for chronic obstructive pulmonary disease, coronary artery disease with post-operative status coronary artery bypass grafting, heart failure with reduced ejection fraction (25%) and atrial fibrillation/flutter underwent an elective ablation of the tachyarrhythmia at another facility and was prescribed amiodarone post procedure. He started complaining of cough and dyspnea one day post procedure and was empirically treated with 2 weeks of broad spectrum antibiotics. He subsequently was transferred to our facility due to worsening symptoms. He also complained of nausea, anorexia with resultant weight loss since starting amiodarone, which was stopped 5 days prior to transfer. Infectious work up was negative.

On arrival to our facility, he was diagnosed with small sub-segmental pulmonary emboli, pulmonary edema and possible acute amiodarone toxicity. His was profoundly hypoxic requiring high flow nasal cannula or 100% non-rebreather mask at all times. His symptoms persisted despite antibiotics, diuresis, anticoagulation and heart rate control. Steroid therapy was then initiated for acute amiodarone toxicity. Although he reported some improvement in symptoms 2-3 days after initiation of steroids, his oxygen requirement did not improve. Unfortunately he suffered a cardiac arrest on day 10 of admission and did not survive.

Amiodarone is a class B anti-arrhythmic used to treat multiple supraventricular and ventricular tachyarrhythmias. Its adverse effects are usually dose and duration dependent. Amiodarone pulmonary toxicity (APT) has been shown to correlate with total cumulative dose; however acute reactions to amiodarone toxicity have previously been reported. Men are at increased risk for APT, and this risk increases with age and those with pre-existing lung conditions. Diagnosis of APT is predominantly a diagnosis of exclusion; however laboratory tests may show leukocytosis with neutrophil predominance (as in our patient) and imaging may provide a clue for diagnosis. Chest x-ray reveals patchy or diffuse infiltrates, which may have predominance in the upper lobes, particularly the right upper lobe (as in our patient). A thoracic CT scan may show bilateral alveolar or interstitial infiltrates with higher attenuation, secondary to the iodine component of the drug. The current mainstay of treatment is discontinuation of the drug permanently along with steroid therapy typically, 40-60 mg of prednisone a day for an extended period of time.  

Konstantin Mazursky DO¹, Bhupinder Natt MD², Laura Meinke MD^1,2

¹Department of Internal Medicine.

²Division of Pulmonary, Critical Care, Allergy and Sleep

Banner-University Medical Center

Tucson AZ

Reference

1. Wolkove N, Baltzan M. Amiodarone pulmonary toxicity. Can Respir J. 2009;16(2):43-8. [PubMed] 

Cite as: Mazursky K, Natt B, Meinke L. Medical image of the week: acute amiodarone pulmonary toxicity. Southwest J Pulm Crit Care. 2015;11(4):189-90. doi: http://dx.doi.org/10.13175/swjpcc099-15 PDF

Medical Image of the Week: PSG Sweat Artifact

Figure 1. A 30 second epoch suggestive of sweat artifact and incidentally noted snore artifact on the M1 channels.

Figure 2: Sweat artifact as seen in a 10 second epoch.

Figure 3.  30 second epoch after removal of the M1 channels.

A 61-year-old man, with a past medical history significant for hypertension, COPD and morbid obesity with a body mass index (BMI) of 45.81 is referred for an overnight sleep study for suspicion of obstructive sleep apnea. Artifact was noted on the polysomnogram recording as shown above (Figures 1-3).

Sweat artifact is characterized by slow undulating movement of the baseline recording in the affected channels due to perspiration altering the potential of the involved electrodes (1). Sweat artifact may mimic delta waves and scored as non-rapid eye movement (NREM) stage 3 sleep. Lowering the room temperature, using a fan on the scalp or replacing the conductive paste on the electrodes may help eliminate the artifact.

Safal Shetty, MD¹ and John Roehrs, MD²

¹Banner University Medical Center Tucson, AZ

²Southern Arizona VA Health Care System

Tucson, AZ

Reference

1. Siddiqui F, Osuna E, Walters AS, Chokroverty S. Sweat artifact and respiratory artifact occurring simultaneously in polysomnogram. Sleep Med. 2006;7(2):197-9. [CrossRef] [PubMed] 

Cite as: Shetty S, Roehrs J. Medical image of the week: PSG sweat artifact. Southwest J Pulm Crit Care. 2015;11(4):171-2. doi: http://dx.doi.org/10.13175/swjpcc097-15 PDF