February 2022 Imaging Case of the Month: Between A Rock and a Hard Place

Michael B. Gotway MD

Department of Radiology, Mayo Clinic, Arizona

5777 East Mayo Boulevard

Phoenix, Arizona USA

Clinical History: A 46-year-old woman presented to her primary care physician with longstanding complaints of difficulty with aerobic exercise, near syncope, headache, poor sleep, and pain in both legs and arms, exacerbated when flying in commercial aircraft. The patient had also complained of several gastrointestinal disturbances recently that prompted evaluation, revealing a normal colonoscopy. The patient was diagnosed with probable food intolerance by breath testing showing fructose intolerance, managed with a low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet with positive results.

PMH, SH, FH: The patient’s past medical history was remarkable for a history of Raynaud’s phenomenon and head trauma at age 16. She noted that her presenting complaints have been present since childhood to some extent. Her poor sleep was characterized as frequent awakenings, daytime somnolence, mouth dryness, and waking up with severe headaches. The patient had been diagnosed with COVID-19 4 months earlier, with her presenting complaints all exacerbated and accompanied by shortness of breath, but she recovered uneventfully. The patient denied other significant past medical history and had no surgical history. Her family history was remarkable for a sister diagnosed with obstructive sleep apnea, diabetes, and thyroid carcinoma, and hypertension in a number of her 13 siblings. The patient’s mother had been diagnosed with colonic malignancy and her father died of melanoma. The patient’s social history was remarkable for abuse during childhood by a male sibling. The patient denied tobacco, alcohol, and illicit drug use.

Physical Examination: The patient’s physical examination showed her to be slender and in no distress although anxious, afebrile, pulse rate= 73, normal respiratory rate, with a blood pressure of 116/95 mmHg. Her cardiovascular, pulmonary, musculoskeletal, and neurologic examinations were within normal limits.

Results from prior outside examinations, including funduscopic, abdominal MRI, and brain MRI and MRA were within normal limits. An outside audiology consultation when the patient complained of hearing loss several months after her SARS-CoV-2 infection showed normal findings. Her complete blood count, coagulation parameters, electrolytes, and liver panel showed no abnormal values. A frontal chest radiograph from an outside institution (Figure 1) from 4 months prior to her primary care appointment, around the time when the patient was diagnosed with COVID-19.

P

Figure 1. Frontal (A) and lateral (B) chest radiography obtained around the time the patient was diagnosed with COVID-19.

Which of the following represents an appropriate interpretation of her frontal chest radiograph? (Click on the correct answer to be directed to the second of 11 pages)

1. Frontal chest radiography shows findings typical for coronavirus (SARS-CoV-2) pulmonary infection
2. Frontal chest radiograph shows bilateral peribronchial lymphadenopathy
3. Frontal chest radiography shows focal consolidation
4. Frontal chest radiography shows multiple lung nodules
5. Frontal chest radiography shows pleural effusion

Cite as: Gotway MB. February 2022 Imaging Case of the Month: Between A Rock in a Hard Place. Southwest J Pulm Crit Care Sleep. 2022;24(2): 12- . doi: https://doi.org/10.13175/swjpccs004-22  PDF

Medical Image of the Month: Cavitating Pseudomonas aeruginosa Pneumonia

Figure 1. A: Admission CXR demonstrates upper lobe bullae and left peri-hilar consolidation on background of emphysema. B: Day 4 CXR reveals more confluent consolidation and opacification of the bullous change. C: Day 8 CXR demonstrates air fluid level with increasing density of consolidation. D: Repeat CXR 6 weeks after discharge shows near complete resolution of findings with small residual cavity.

Figure 2. CT Chest with contrast confirmed extensive consolidation with cavitation and suggested possibility of atypical infection

Case Presentation

A 56-year-old woman presented with cough and shortness of breath to hospital. She had a temperature of 39.2°C and had recently completed course of steroids and antibiotics for exacerbation of chronic obstructive pulmonary disease (COPD). She was an active smoker of 15 cigarettes/day for about 40 years. No other past medical history was noted. On examination she had left-sided crepitations and oxygen saturations of 90% on room air.

Chest x-ray (CXR) (Fig 1:A) showed features of background emphysema with upper lobe peripheral bullae, larger on the left. Dense left peri-hilar consolidation was also described. SARS-CoV-2 swab was negative. White blood cells (WBC) were raised at 16.9x10⁹/L and C-reactive protein (CRP) at 331 mg/L. The rest of the blood tests were unremarkable. CURB-65 score was zero but treatment was commenced with intravenous (IV) amoxicillin & oral clarithromycin in view of level of CRP and CXR findings. On Day 4 of admission CRP spiked to 541 mg/L. Repeat CXR (Fig 1:B) showed more confluent left upper zone consolidation and increased opacification of bullous change in the left apex. Microbiologist advised switch of IV Amoxicillin to IV Co-amoxiclav. Respiratory colleagues suggested to check sputum for acid-fast bacilli (AFB). Pneumococcal & legionella urinary antigens came back negative. HIV was also excluded. Growth of Pseudomonas aeruginosa was detected on a blood-tinged sputum sample which was confirmed on 3 more subsequent samples. AFB stain was persistently negative. Blood cultures did not yield any growth.

Antibiotic therapy was escalated to IV piperacillin/tazobactam (Tazocin; Pfizer; UK) QDS (Pseudomonas dose) in light of the new finding. Inflammatory markers slowly started to shift but intermittent temperature spikes continued so repeat CXR (Fig 1:C) and subsequent computed tomography (CT) of chest with contrast (Fig 2) were obtained to assess the complex pneumonia with its striking appearances. CT confirmed extensive consolidation with cavitation and air-fluid levels in the left apical region. Patient required 2L/min supplemental oxygen at the time. By completion of 7-day course of IV piperacillin/tazobactam CRP dropped to 63 mg/L and WBC to 8.6x10⁹/L. Patient was successfully weaned off oxygen and discharged home. Repeat CXR in 6 weeks (Fig 1:D) showed marked improvement with residual small cavity.

Discussion

P. Aeruginosa - a gram negative rod is a rare cause of both CAP (community acquired pneumonia) and cavitating pneumonia. It is more commonly associated with hospital acquired pneumonia (HAP) and usually affects immunocompromised hosts (1). Cavitating pneumonia arises as a result of necrosis of lung parenchyma due to toxins derived from bacterial pathogens. Maharaj et al. (2) reviewed 9 cases of P. Aeruginosa CAP reported on PubMed from 2001 to 2016 and 5 out of 9 patients were found to be smokers. Emphysema was reported in 2 and asthma only in 1 case. The pneumonia exclusively affected upper lobes in 8 out of 9 cases. The infection was fatal in 3 cases (mean age 54) through development of septic shock. Early identification and timely treatment of P. Aeruginosa infection is crucial due to its high rate of multi-drug resistance (3). In absence of positive sputum cultures clinical suspicion based on imaging could drastically change patient’s course of illness. Presentation of upper-lobe pneumonia not responding to standard antibiotic regimens should alert clinicians to the differential of P. Aeruginosa infection. Plain radiograph usually gives sufficient information in CAP but a CT scan may be warranted on an individual basis to assess more complex pneumonia. 

Giorgi Kiladze MBcHB, MRCP(UK)

Royal Liverpool and Broadgreen University Hospitals NHS Trust

Prescot Street, Liverpool, Merseyside, UK L7 8XP

References

1. Rello J, Borgatta B, Lisboa T. Risk factors for Pseudomonas aeruginosa pneumonia in the early twenty-first century. Intensive Care Med. 2013 Dec;39(12):2204-6. [CrossRef] [PubMed]
2. Maharaj S, Isache C, Seegobin K, Chang S, Nelson G. Necrotizing Pseudomonas aeruginosa Community-Acquired Pneumonia: A Case Report and Review of the Literature. Case Rep Infect Dis. 2017;2017:1717492. [CrossRef] [PubMed]
3. Wolter DJ, Lister PD. Mechanisms of β-lactam resistance among Pseudomonas aeruginosa. Curr Pharm Des. 2013;19(2):209-22.

Abbreviations

• COPD – Chronic Obstructive Pulmonary Disease
• CXR – Chest X-ray
• WBC – White Blood Cells
• CRP – C Reactive Protein
• CURB 65 – Confusion Urea Respiratory rate Blood pressure Age 65
• IV – Intravenous
• AFB – Acid-Fast Bacilli
• HIV – Human Immunodeficiency Virus
• QDS – Quarter Die Sumendum (four times daily)
• CT – Computed Tomography
• L/min – Litres/minute
• CAP – Community Acquired Pneumonia
• HAP – Hospital Acquired Pneumonia

Cite as: Kiladze G. Medical Image of the Month: Cavitating Pseudomonas aeruginosa Pneumonia. Soulthwest J Pulm Crit Care. 2021;23(5):126-8. doi: https://doi.org/10.13175/swjpcc034-21 PDF

Medical Image of the Month: Mucinous Adenocarcinoma of the Lung Mimicking Pneumonia

Figure 1. A contrasted, coronal-reformatted CT image of the chest demonstrates unilateral ground glass opacification of the right lung with superimposed interlobular septal thickening (blue arrows). There is also volume loss of the left lung with elevation of the left hemidiaphragm (red arrow).

Clinical Scenario: A 60-year-old man with a history of chronic obstructive pulmonary disease presented to the hospital with worsening shortness of breath over a period of 3 days. He had a 50-pack-year history of smoking, coronary artery disease, and a previous history of a left lung mass of unknown pathology status post left upper lobectomy. He was bought to the emergency room via ambulance after being found at home with oxygen saturations in the 60s. Upon arrival to the emergency room, he required continuous oxygen at 15 L/min to maintain his oxygen saturations above 88%. He had a progressive, markedly productive cough over the last few weeks prior to presentation. He had been treated for pneumonia with multiple courses of antibiotics over the last two months without any significant improvement. His blood work was significant for a leukocytosis with neutrophilia and an elevated D-dimer. He underwent a CTA of the chest in the emergency room to evaluate for a pulmonary embolism. The CTA of the chest had no evidence of pulmonary thromboembolic disease. However, there was unilateral ground glass opacification of the right lung with interlobular septal thickening along with volume loss of the left lung and associated elevation of the left hemidiaphragm (Figure 1). He was admitted to the medical ICU and started on broad-spectrum antibiotics. He underwent a bronchoscopy which demonstrated mucinous adenocarcinoma of the lung. His oxygen requirement was eventually weaned after multiple days in the ICU. He was discharged with follow up in the oncology clinic.

Discussion: Mucinous adenocarcinoma of the lung is the rarest type of adenocarcinoma of the lung. It is characterized as mucinous adenocarcinoma in situ, minimally invasive adenocarcinoma, and invasive mucinous adenocarcinoma. Mucinous adenocarcinoma of the lung is morphologically characterized by tall columnar cells with abundant cytoplasm that contain varying amounts of mucin. Mucus secreted by these cells can commonly be discharged as sputum. However, if airway obstruction occurs secondary to excessive mucus production, a post-obstructive pneumonia may develop. The prognosis of mucinous adenocarcinoma of the lung is poor.

Nicholas Blackstone MD¹, Tammer El-Aini MD²

¹Department of Internal Medicine and ²Department of Pulmonary and Critical Care, South Campus, Banner University Medical Center – Tucson, Tucson, AZ USA

References

1. Liu Y, Zhang HL, Mei JZ, Guo YW, Li RJ, Wei SD, Tian F, Yang L, Wang H. Primary mucinous adenocarcinoma of the lung: A case report and review of the literature. Oncol Lett. 2017 Sep;14(3):3701-3704. [CrossRef] [PubMed]
2. Marchetti A, Buttitta F, Pellegrini S, Chella A, Bertacca G, Filardo A, Tognoni V, Ferreli F, Signorini E, Angeletti CA, Bevilacqua G. Bronchioloalveolar lung carcinomas: K-ras mutations are constant events in the mucinous subtype. J Pathol. 1996 Jul;179(3):254-9. [CrossRef] [PubMed]
3. Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D. International association for the study of lung cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol. 2011 Feb;6(2):244-85. [CrossRef] [PubMed]
4. Cai D, Li H, Wang R, Li Y, Pan Y, Hu H, Zhang Y, Gong R, Pan B, Sun Y, Chen H. Comparison of clinical features, molecular alterations, and prognosis in morphological subgroups of lung invasive mucinous adenocarcinoma. Onco Targets Ther. 2014 Nov 18;7:2127-32. [CrossRef] [PubMed].
5. Xie GD, Liu YR, Jiang YZ, Shao ZM. Epidemiology and survival outcomes of mucinous adenocarcinomas: A SEER population-based study. Sci Rep. 2018 Apr 17;8(1):6117. [CrossRef] [PubMed]

Cite as: Blackstone N, El-Aini T. Medical image of the month: mucinous adenocarcinoma of the lung mimicking pneumonia. Southwest J Pulm Crit Care. 2021;22(1):8-10. doi: https://doi.org/10.13175/swjpcc072-20 PDF

Medical Image of the Month: Viral Pneumonias

Figure 1. Pulmonary viral infection spectrum on thoracic CT scan in lung windows: A= Coronavirus NL63; B= Adenovirus; C= Influenza AH1 2009; D= COVID-19; E= Coronavirus HKU1; F= Influenza AH1 2009.

Numerous viruses, including the corona, influenza and adenoviruses can cause lower respiratory tract infection in adults (1). Viral pneumonia in adults can be classified into two clinical groups: so-called atypical pneumonia in otherwise healthy hosts and viral pneumonia in immunocompromised hosts. Until the COVID-19 pandemic, influenza virus types A and B caused most cases of viral pneumonia in immunocompetent adults. Immunocompromised hosts are susceptible to pneumonias caused by a wide variety of viruses including cytomegalovirus, herpesviruses, measles virus, and adenovirus. The CT imaging findings consist mainly of patchy or diffuse ground-glass opacity, with or without consolidation, and reticular areas of increased opacity, are variable and overlapping. The imaging findings in COVID-19 pneumonia are generally not distinctive compared to other viral pneumonias, including other coronaviruses such as SARS and MERS (2). A recent study systematically reviewed the longitudinal changes of CT findings in COVID-19 pneumonia. The results suggested that the lung abnormalities increase quickly after the onset of symptoms, peak around 6-11 days, and are followed by persistence of the findings.

Bacterial pneumonias may also take multiple forms and are sometimes difficult to radiographically separate from viral pneumonia (3). However, the presence of ground-glass opacities alone is unusual for a bacterial pulmonary infection. Rather, bacterial infections commonly present as areas of consolidation with air bronchogram formation, centrilobular nodules (often with branching configurations) and airway thickening.

Michael B. Gotway MD

Department of Radiology

Mayo Clinic Arizona

Scottsdale, AZ USA

References

1. Kim EA, Lee KS, Primack SL, et al. Viral pneumonias in adults: radiologic and pathologic findings. Radiographics. 2002 Oct;22 Spec No:S137-49. [CrossRef] [PubMed]
2. Wang Y, Dong C, Hu Y, Li C, Ren Q, Zhang X, Shi H, Zhou M. Temporal Changes of CT Findings in 90 Patients with COVID-19 Pneumonia: A Longitudinal Study. Radiology. 2020 Mar 19:200843. [CrossRef] [PubMed]
3. Panse PM, Jokerst CE, Gotway MB. May 2020 Imaging Case of the Month: Still Another Emerging Cause for Infiltrative Lung Abnormalities. Southwest J Pulm Crit Care. 2020. May 1. (in press). [CrossRef]

Cite as: Gotway MB. Medical image of the month: viral pnuemonias. Southwest J Pulm Crit Care. 2022;20(5):163-4. doi:  https://doi.org/10.13175/swjpcc028-20 PDF 

May 2020 Imaging Case of the Month: Still Another Emerging Cause for Infiltrative Lung Abnormalities

Prasad M. Panse MD

Clinton E. Jokerst MD

Michael B. Gotway MD

Department of Radiology

Mayo Clinic, Arizona

Scottsdale, Arizona 85054

Clinical History: A 46-year-old man with a history of well-controlled asthma presented to the Emergency Room with complaints of worsening non-productive cough for 4-5 days followed by fever to 104°F over the previous 3 days. The patient also complained of some chills and loose stools. The patient denied rhinorrhea, sore throat, congestion, and nausea or vomiting. The patient also denied illicit drug use, and drinks alcohol only occasionally and denied smoking.

The patient’s physical examination showed a pulse rate of 79 / minute and a respiratory rate of 18 / minute, although his blood pressure was mildly elevated at 149/84 mmHg; he was afebrile with a temperature of 97.7 °F (36.5 °C). The patient’s room air oxygen saturation was 98%. The physical examination showed some mild expiratory wheezes bilaterally, but was otherwise entirely within normal limits.

Which of the following represents the most appropriate step for the patient’s management? (Click on the correct answer to be directed to the second of twelve pages)

1. Obtain a complete blood count
2. Obtain a travel history
3. Obtain serum chemistries
4. Perform chest radiography
5. All of the above

Cite as: Panse PM, Jokerst CE, Gotway MB. May 2020 imaging case of the month: still another emerging cause for infiltrative lung abnormalities. Southwest J Pulm Crit Care. 2020;20(5):147-62. doi: https://doi.org/10.13175/swjpcc027-20 PDF 

Medical Image of the Month: Penicillium Pneumonia Presenting as a Lung Mass

Figure 1. Representative image from thoracic CT scan in lung windows.

Figure 2. Panel A: Culture plate showing growth on culture plate. Panel B: Photomicrograph showing the dimorphic fungus taken from the culture plate.

A 72-year-old woman who is a non-smoker was referred for evaluation of a suspected lung cancer. She had progressive shortness of breath at rest for 5 months associated with right-sided chest pain, cough and yellowish sputum. She failed multiple courses of antibiotics.

Her past medical history was significant for hypertension, dyslipidemia, hypothyroidism and poorly controlled diabetes mellitus type 2. She also had mild coronary artery disease for which she was on dual antiplatelet therapy. On physical examination, her oxygen saturation was 94% on room air her other vital signs also being unremarkable. Her physical exam revealed decreased breath sounds on the right associated with dullness to percussion.

Her chest radiograph demonstrated right middle lobe opacities. Her chest CT showed a right hilar mass surrounded by multiple nodules along with interlobular septal thickening, a right middle lobe consolidation with air bronchograms, and multiple mediastinal lymph nodes – all suggestive of malignancy (Figure1).

The patient underwent bronchoalveolar lavage and multiple transbronchial biopsies from the right upper and right middle lobes. The lung biopsy showed nonspecific lymphocytic inflammatory infiltrates. Her bronchoalveolar lavage was positive for fungus on PAS stain. The BAL culture showed germ tube negative yeast, which were identified to be Penicillium species (Figure 2).

Fungi are uncommon causes of pneumonia in the general population, but they are more prevalent in immunocompromised hosts with HIV infection, bone marrow transplant, patients on steroids, or patients with neutropenia (1). Penicillium are thermally dimorphic fungi, widely spread in the environment (2). They found especially in soil or where decaying organic material is present. They are saprophytic and capable of causing food spoilage. Patients usually inhale the spores of penicillium present in soil, and so lungs are the primary site of infection. However, disseminated Penicilliosis with lymphadenopathy and organomegaly (especially in immunocompromised patients) can be seen. There was no evidence of disseminated Penicilliosis in our patient. She was not immunocompromised, and her only risk factor was poorly-controlled diabetes mellitus. If not recognized early, Penicillium pneumonia can be fatal. The diagnosis depends on obtaining tissue, sputum and/or BAL samples for fungal cultures. Use of a serum galactomannan antigen assay may facilitate earlier diagnosis of Penicillium infections, however it is not specific for this pathogen as it is a polysaccharide cell wall component of most Aspergillus species as well (3).

There is no consensus about the treatment of Penicillium pneumonia, however standard therapy consists of intravenous amphotericin B, followed by oral itraconazole for several weeks. The optimal duration of treatment is unknown as several cases of relapse have been reported in the literature.

The patient received two weeks of intravenous amphotericin B deoxycholate followed by 12 months of oral itraconazole. The patient improved significantly with resolution of the consolidation seen on her previous chest radiography.

Hasan S. Yamin MD¹, Amro Alastal MD², Abbas Iter MD¹, Murad Azamttah¹

¹Pulmonary and Critical Care, An-Najah University Hospital, Nablus, Palestine

²Pulmonary and Critical Care, Marshall University, WV, USA

References

1. Kang Y, Feitelson M, de Hoog S, Liao W. Penicillium marneffei and its pulmonary Involvements. Current Respiratory Medicine Reviews. 2012;8(5):356-64. [CrossRef]
2. Visagie CM, Houbraken J, Frisvad JC, Hong SB, Klaassen CH, Perrone G, Seifert KA, Varga J, Yaguchi T, Samson RA. Identification and nomenclature of the genus Penicillium. Stud Mycol. 2014 Jun;78:343-71. [CrossRef] [PubMed]
3. Hung CC, Chang SY, Sun HY, Hsueh PR. Cavitary pneumonia due to Penicillium marneffei in an HIV-infected patient. Am J Respir Crit Care Med. 2013 Jan 15;187(2):e3-4. [CrossRef][PubMed]

Cite as: Yamin HS, Alastal A, Iter A, Azamttah M. Medical image of the month: Penicillium pneumonia presenting as a lung mass. Southwest J Pulm Crit Care. 2019;19:164-6. doi: https://doi.org/10.13175/swjpcc033-19 PDF 

Medical Image of the Week: Acute Pneumonitis Secondary to Boric Acid Exposure

Figure 1. Panel A: A normal baseline chest radiograph obtained a few months prior to the current presentation. Panel B: A chest radiograph obtained at the day of admission with respiratory distress post exposure to boric acid powder that shows diffuse hazy opacities of the lungs. Panel C: Representative image form thoracic computed tomography obtained on day of admission shows extensive diffuse central predominant ground glass opacification. Panel D: A chest radiograph obtained 3 days after large dose of systemic steroid given for a presumptive diagnosis of acute pneumonitis. Rapid improvement of the bilateral airspace disease is suggestive of resolving inflammation.

Figure 2. Video of thoracic computed tomorgraphy in lung windows obtained on the day of admission.

A 33-year-old man presented with acute severe dyspnea and pleuretic chest pain one day after accidental inhalational exposure to boric acid powder. The patient was spraying boric acid in his apartment to kill bugs and he got trapped in a poorly ventilated area with a cloud of the dusted boric acid for more than a minute. He did not feel any significant symptoms initially. Overnight he started to develop shortness of breath and chest tightness. The patient visited an urgent care where he was reassured due to normal chest radiograph and was given a course of oseltamivir empirically due to a widespread influenza epidemic. After a few hours the patient’s symptoms got much worse and he presented to the emergency department with severe pleuretic chest pain and respiratory distress. The patient required 5 liters of oxygen to keep his saturation above 90%. His chest images showed extensive bilateral airspace disease suggestive of either pulmonary edema, multifocal pneumonia or inflammatory pneumonitis. His microbiologic work up was negative including influenza PCR. Echocardiogram was normal. With his recent exposure to boric acid inhalation an acute chemical pneumonitis was suspected. The patient received systemic high dose prednisone for 3 days and he improved significantly clinically and on imaging. His oxygen saturation was 97% on room air 4 days post admission.

Boric acid is an odorless partially water-soluble antiseptic, insecticide, flame retardant, neutron absorber, and a precursor to other chemical compounds (1,2). The material safety data sheet for boric acid suggests that it may be also toxic to kidneys, cardiovascular system, central nervous system (CNS) (2). Repeated or prolonged exposure to the substance can produce target organ damage (1,2)

Huthayfa Ateeli, MBBS¹, Laila Abu Zaid, MD², Sachin Chaudhary, MD¹

¹Pulmonary and Critical Care Division, Department of Medicine, University of Arizona, Tucson, AZ USA

²Department of Medicine, University of Arizona, Tucson, AZ USA

References

1. Agency for Toxic Substances & Disease Registry. Toxicological profile of boron. November 2010. Available at: https://www.atsdr.cdc.gov/toxprofiles/tp26.pdf (accessed 2/27/18).
2. ScienceLab.com. Material Safety Data Sheet: Boric acid MSDS. October 10, 2005. May 21, 2013. Available at: http://www.sciencelab.com/msds.php?msdsId=9927105 (accessed 2/27/18).

Cite as: Ateeli H, Zaid LA, Chaudhary A. Medical image of the week: acute pneumonitis secondary to boric acid exposure. Southwest J Pulm Crit Care. 2018;16(2):108-9. doi: https://doi.org/10.13175/swjpcc025-18 PDF 

Medical Image of the Week: Mucous Plugs Forming Airway Casts

Figure 1. Bronchoscopic view of the mucous plug.

Figure 2. Cast removed with cryo-adhesion probe.

A 64 -year-old man with a recent diagnosis of acute lymphocytic leukemia (ALL) on chemotherapy presented with acute hypoxic respiratory failure, multifocal pneumonia, neutropenic fever and septic shock. The patient was intubated and required vasopressors for septic shock. His blood and sputum cultures grew Pseudomonas aeruginosa. Chest computed tomography demonstrated extensive consolidation of the left lung mainly the left lower lobe with extensive endobronchial mucus plugs. The patient underwent bronchoscopy after noninvasive measures failed to resolve the left lung atelectasis. After multiple attempts to retrieve the mucus plugs (Figure 1) with suction failed, a cryo-adhesion probe was used to freeze and retrieve the mucus plug. The plug formed a cast taking the shape of the airway (Figure 2).

Flexible bronchoscopy is warranted in patients who have persistent atelectasis or pneumonia that is either of unknown cause or suspected of being due to airway obstruction (1). The use of cryo-adhesion and extraction has been particularly useful in the management of airway obstruction caused by foreign bodies especially mucus plugs and blood clots that are not easily extracted by more standard means such as suction or forceps (2).

Huthayfa Ateeli, MBBS and Cameron Hypes MD, MPH

Division of Pulmonary, Critical Care, Sleep and Allergy Medicine

University of Arizona, Tucson, AZ USA

References

1. Feinsilver SH, Fein AM, Niederman MS, Schultz DE, Faegenburg DH. Utility of fiberoptic bronchoscopy in nonresolving pneumonia. Chest. 1990 Dec;98(6):1322-6. [CrossRef] [PubMed]
2. Strausz J, Bolliger CT. Interventional pulmonology. Sheffield: European Respiratory Society; 2010: 165.

Cite as: Ateeli H, Hypes C. Medical image of the week: mucous plugs forming ariway casts. Southwest J Pulm Crit Care. 2017;15(6):278-9. doi: https://doi.org/10.13175/swjpcc147-17 PDF 

October 2017 Imaging Case of the Month

Paul J. Conomos, MD¹

Michael B. Gotway, MD²

¹Arizona Pulmonary Specialists

Phoenix, AZ USA

²Mayo Clinic Arizona

Scottsdale, AZ USA

Clinical History: An 18-year-old man with no known previous medical history presented with complaints of intermittent cough persisting several months. No hemoptysis was noted.

Physical examination was largely unremarkable and the patient’s oxygen saturation was 99% on room air. The patient’s vital signs were within normal limits.

Laboratory evaluation was unremarkable.  Quantiferon testing for Mycobacterium tuberculosis was negative, and testing for coccidioidomycosis was unrevealing. Frontal and lateral chest radiography (Figure 1) was performed.

Figure 1. Figure 1. Frontal (A) and lateral (B) chest radiography.

Which of the following statements regarding the chest radiograph is most accurate? (Click on the correct answer to proceed to the second of eight pages)

1. The chest radiograph shows asymmetric reticulation and interlobular septal thickening
2. The chest radiograph shows bilateral reticulation associated with decreased lung volumes
3. The chest radiograph shows focal consolidation
4. The chest radiograph shows large lung volumes
5. The chest radiograph shows small cavitary pulmonary nodules

Cite as: Conomos PJ, Gotway MB. October 2017 imaging case of the month. Southwest J Pulm Crit Care. 2017;15(4):138-46. doi: https://doi.org/10.13175/swjpcc119-17 PDF

August 2017 Imaging Case of the Month

Brandon T. Larsen, MD, PhD¹

Michael B. Gotway, MD²

Departments of Pathology¹ and Radiology²

Mayo Clinic Arizona

Scottsdale, Arizona USA

Clinical History: A 67-year-old man with a 23 pack-year history of smoking, stopping 6 years earlier, presented with a year-long history of intermittent hemoptysis consisting of small specs of blood particularly in the morning after he awoke. No sputum discoloration was reported and the patient denied shortness of breath, fever, shortness of breath, and chills. The patient also denied rash, joint pain, and night sweats. His past surgical history was remarkable only for an appendectomy, tonsillectomy, and repair of an ankle fracture, all as a young man. The patient did report some asbestos exposure in the past. He takes a multivitamin and occasional over-the counter pain relievers, but was not taking prescription medications.

Physical examination: unremarkable and the patient’s oxygen saturation was 98% on room air.

Laboratory evaluation: largely unremarkable.  Quantiferon testing for Mycobacterium tuberculosis was negative. An outside otolaryngology examination was reported to show no abnormalities. Frontal chest radiography (Figure 1) was performed.

Figure 1.  Frontal chest radiography.

Which of the following statements regarding the chest radiograph is most accurate? (Click on the correct answer to proceed to the second of nine pages)

1. The chest radiograph shows a mediastinal mass
2. The chest radiograph shows multifocal consolidation and pleural effusion
3. The chest radiograph shows multifocal smooth interlobular septal thickening
4. The chest radiograph shows a possible focal air space opacity
5. The chest radiograph shows small cavitary pulmonary nodules

Cite as: Larsen BT, Gotway MB. August 2017 imaging case of the month. Southwest J Pulm Crit Care. 2017;15(2):69-79. doi: https://doi.org/10.13175/swjpcc098-17 PDF

July 2017 Imaging Case of the Month

Michael B. Gotway, MD

Department of Radiology

Mayo Clinic Arizona

Scottsdale, Arizona USA

Clinical History: A 56-year-old man with no significant past medical history presented with complaints of cough, shortness of breath, and productive sputum. Frontal and lateral chest radiography (Figure 1) was performed.

Figure 1. Frontal (A) and lateral (B) chest radiography.

Which of the following statements regarding the chest radiograph is most accurate? (Click on the corect answer to proceed to the second of nine pages)

1. The chest radiograph shows a diffuse linear, interstitial pattern
2. The chest radiograph shows a large pleural effusion
3. The chest radiograph shows a mediastinal mass
4. The chest radiograph shows numerous small nodules
5. The chest radiograph shows right lower lobe consolidation

Cite as: Gotway MB. July 2017 imaging case of the month. Southwest J Pulm Crit Care. 2017;15(1):17-27. doi: https://doi.org/10.13175/swjpcc090-17 PDF 

Medical Image of the Week: Zenker’s Diverticulum

Figure 1. Panel A: PA view chest x-ray shows possible cavitation with air-fluid level in the right upper lobe (arrow). Panel B: lateral view chest x-ray shows possible cavitation with air-fluid level in the right upper lobe (arrow).

Figure 2. Coronal section of the thoracic CT scan shows focal dilation of the upper thoracic esophagus which contains fluid (arrow).

Figure 3.  Endoscopic view of the upper esophagus showing the diverticulum with impacted food bolus.

A 71-year-old man with history of recurrent aspiration pneumonia and previous esophageal surgery presented to the Emergency Department with acute hypoxia and leukocytosis. Imaging, above, showed a consolidation in the RUL and on lateral view an air fluid level. This was suspicious for infection or malignancy. For the ongoing concern for possible esophageal pathology given previous surgery, GI was consulted and upper endoscopy performed.  He was found to have an esophageal dilation at repair site of a previous Zenker’s diverticulum filled with food.

Zenker’s Diverticulum is a defect in the muscular wall of the hypopharynx in an area known as Killian's triangle. This condition is male predominant mainly occurring in the 3^rd to 4^th decade and/or the 7^th to 8^th decade of life.  The out pouching created will accumulate food and eventually lead to high incidences of aspiration pneumonia. Treatment is usually surgical in nature and can cause vocal cord damage and even recurrence of the outpouching (1).  

Chandra Stockdall MD and Roberto Swazo MD

Department of Internal Medicine

Banner University Medical Center South Campus

Tucson, AZ USA

Reference

1. Mulder C, Van Delft F. Zenker’s diverticulum. UpToDate. May, 2017. Available at: http://www.uptodate.com/contents/zenkers-diverticulum (requires subscription, accessed 6/30/17).

Cite as: Stockdall C, Swazo R. Medical image of the week: Zenker's diverticulum. Southwest J Pulm Crit Care. 2017;15(1):15-6. doi: https://doi.org/10.13175/swjpcc075-17 PDF

Medical Image of the Week: Staphylococcal Pneumonia in a Patient with Influenza

Figure 1. Thoracic CT scan axial view demonstrating bilateral cavitary infiltrates.

A 63-year-old, obese diabetic man presented to his primary care physician with complaints of fever, headache, myalgias, and cough. A nasal swab specimen was positive for influenza A by fluorescent immunoassay. Therapy with oseltamivir was initiated. The patient’s symptoms progressed and he was transported to the emergency department , where he was found to have a room air oxygen saturation of 74%, bilateral basilar infiltrates on chest radiograph, a white blood count of 24.2 K/uL and a procalcitonin level of 12.66 ng/ml. He was placed on BIPAP with high flow supplemental oxygen,  started on empiric intravenous antibiotic therapy with vancomycin and piperacillin/tazobactam, and admitted to the intensive care unit.  Blood and sputum cultures were eventually positive for methicillin-sensitive Staphylococcus aureus, and the patient’s antibiotic therapy was de-escalated to nafcillin. On hospital day 5, a CT of the chest obtained to evaluate pleuritic pain revealed extensive bilateral cavitary infiltrates (Figure 1). The patient’s discomfort resolved without further intervention, he continued to improve, and was uneventfully transitioned to oral therapy. 

S. aureus pneumonia is characterized by high fever, productive cough, and a radiographic pattern of patchy, often multilobar, infiltrates which may exhibit cavitary change.  In the USA, approximately 2% of patients admitted to the hospital for treatment of community-acquired pneumonia demonstrate microbiologic evidence of S. aureus infection (1). There is a slight predominance of methicillin sensitive species (MSSA) compared to methicillin resistant species (MRSA).  Morbidity and mortality are both high, with over 80% of patients requiring care in the ICU, and a fatality rate of 13% (2).

Among patients admitted to the intensive care unit with a primary diagnosis of influenza, there is a 15% incidence of S. aureus pneumonia. Risk factors for co-infection in this setting  include obesity, HIV infection, and immunosuppressive medication. There is a robust association between bacteremia and mortality (3).  Early empiric antibiotic therapy with an agent active against S. aureus should be strongly considered for patients admitted to the ICU with influenza complicated by pneumonia, pending the return of blood and respiratory cultures.

¹Charles VanHook, ²Kristin Dahlem, and ¹Angela Taylor

¹Longmont United Hospital, Longmont, Colorado USA

²Massachusetts College of Pharmacy and Health Sciences, Boston, Massachusetts USA

References

1. Jain S, Self WH, Wunderink R, et al. Community-acquired pneumonia requiring hospitalization among U.S. adults. N Engl J Med. 2015 Jul 30;373(5):415-27. [CrossRef] [PubMed]
2. Self WH, Wunderink RG, Williams DJ, et al. Staphylococcus aureus community-acquired pneumonia: prevalence, clinical characteristics, and outcomes. Clin Infect Dis. 2016 Aug 1;63(3):300-9. [CrossRef] [PubMed]
3. Martin-Loeches I, J Schultz M, et al. Increased incidence of co-infection in critically ill patients with influenza. Intensive Care Med. 2017 Jan;43(1):48-58. [CrossRef] [PubMed]

Cite as: VanHook C, Dahlem K, Taylor A. Medical image of the week: staphylococcal pneumonia in a patient with influenza. Southwest J Pulm Crit Care 2017:14(4):170-1. doi: https://doi.org/10.13175/swjpcc045-17 PDF

Medical Image of the Week: Papillomatosis

Figure 1. Chest roentgenogram.

Figure 2. Contrast enhanced computer tomography of chest.

A 24-year-old man with recurrent respiratory papillomatosis presented with a history of breathlessness and a change in voice for the last four months. He had undergone endoscopic debridement in the past for laryngeal papillomatosis. On initial evaluation, respiratory distress was thought to be due to recurrence of laryngeal papillomatosis as he improved after surgical de-bulking of laryngo-tracheal papillomas. However, he had some trickle of blood into bronchi with debridement under general anaesthesia. Post-operative chest roentgenogram showed bilateral patchy opacities giving the appearance of aspiration pneumonitis as shown in figure 1.

He also underwent contrast enhanced computer tomography of the chest which showed numerous but small cavitary lesions involving bilateral lung parenchyma as shown in figure 2. This lead to the diagnosis of pulmonary spread of laryngeal papillomatosis and the patient was given adjuvant treatment for this aggressive disease (1,2).

K Devaraja, MS, DNB and Kapil Sikka, MS, DNB

All India Institute of Medical Sciences

Ansari Nagar, New Delhi, India

References

1. Abe K, Tanaka Y, Takahashi M, Kosuda S, et al. Pulmonary spread of laryngeal papillomatosis: radiological findings. Radiat Med. 2006 May;24(4):297–301. [CrossRef] [PubMed]
2. Carifi M, Napolitano D, Morandi M, Dall'Olio D. Recurrent respiratory papillomatosis: current and future perspectives. Ther Clin Risk Manag. 2015;11:731–8. [CrossRef] [PubMed] 

Cite as: Devaraja K, Sikka K. Medical image of the week: papillomatosis. Southwest J Pulm Crit Care. 2017;14(3):123-4. doi: https://doi.org/10.13175/swjpcc025-17 PDF

Medical Image of the Week: Infected Emphysematous Bulla

Figure 1. Portable AP chest X-ray revealing dense opacity within the lingula of left lung.

Figure 2. Thoracic CT with contrast showing lobar consolidation with increased lucency compatible with emphysema.

Figure 3. (A) Chest CT one year prior demonstrating severe emphysema. (B) Chest CT on admission showing new fluid-filled bulla (red arrow) in the setting pneumococcal pneumonia.

A 65 year-old man with chronic obstructive lung disease (COPD), hypertension and alcohol abuse presented to the emergency department with complaints of feeling unwell and shortness of breath. He was tachycardic but otherwise hemodynamically stable, afebrile, and requiring 3 liters/min supplemental oxygen. Pertinent initial laboratory findings revealed a neutrophilic predominant leukocytosis (WBC 37.8 x 10³ micro/L) with lactic acidosis (2.7 mMol/L). Chest radiograph showed a dense opacity within the region of the lingula (Figure 1). Follow-up CT chest confirmed a consolidation likely representing lobar pneumonia in the setting of severe bullous emphysema (Figure 2). A large fluid-containing emphysematous bulla (Figure 3) was present which was not visualized one year prior. 

He was started on broad spectrum antibiotics after peripheral blood cultures were drawn which revealed Streptococcus pneumoniae. Broad spectrum antibiotics were discontinued and patient was started on intravenous ceftriaxone 2g every 24 hours. He improved clinically and was discharged home after 4 days.

Pneumococcal pneumonia remains the most common cause of community-acquired pneumonia and accounts for nearly 66% of all bacteremic pneumonias (1,2). Our patient had multiple risk factors for developing pneumococcal pneumonia including alcohol abuse, COPD, and history of cigarette smoking. Pneumococcal pneumonia often causes dense consolidation within the lung in a well-defined lobar or segmental distribution. In emphysema areas of lucency may be seen within the consolidation which may mimic other processes such as necrosis. The pathogenesis of fluid accumulation in an emphysematous bulla is not well understood but can be associated with severe lung infection (3). Percutaneous drainage is not recommended and bronchoscopy is not usually required unless there is another indication (3). Antibiotic therapy in those who are asymptomatic has not shown to add any benefit in resolution or preventing infection (3).

Norman Beatty MD¹, Kyle McKeown MPH², Kelly M. Hager MPH², and Stephen J. Scholand MD³

¹ Department of Medicine, Banner-University Medical Center South, Tucson, AZ USA

² University of Arizona College of Medicine, Tucson, AZ USA

³ Division of Infectious Diseases, Department of Medicine, MidState Medical Center, Meriden, CT USA

References

1. Torres A, Peetermans WE, Viegi G, Blasi F. Risk factors for community-acquired pneumonia in adults in Europe: a literature review. Thorax. 2013 Nov;68(11):1057-65. [CrossRef] [PubMed]
2. Fine MJ, Smith MA, Carson CA, Mutha SS, Sankey SS, Weissfeld LA, Kapoor WN. Prognosis and outcomes of patients with community-acquired pneumonia. A meta-analysis. JAMA. 1996 Jan 10;275(2):134-41. [CrossRef] [PubMed]
3. Chandra D, Rose SR, Carter RB, Musher DM, Hamill RJ. Fluid-containing emphysematous bullae: a spectrum of illness. Eur Respir J. 2008 Aug;32(2):303-6. [CrossRef] [PubMed]

Cite as: Beatty N, McKeown K, Hager KM, Scholand SJ. Medical image of the week: infected emphysematous bulla. Southwest J Pulm Crit Care. 2016;14(1):37-8. doi: https://doi.org/10.13175/swjpcc006-17 PDF 

Medical Image of the Week: Tracheobronchial Foreign Body Aspiration

Figure 1. Panel A: The chest x-ray failed to show the aspirated foreign body. Panels B and C: Flexible bronchoscopy was performed and the insulin syringe cap was visualized in the right mainstem bronchus and retrieved with forceps.

Figure 2. Panel A: CT chest shows interval development of ground glass opacities and air fluid level in the right middle lobe (arrow). Panel B: The foreign body is visualized in the right lower lobe bronchus as an endobronchial-filling defect (arrow). Panel C: Flexible bronchoscopy was performed and cashew piece was retrieved with suction.

Case 1 (Figure 1) is a 58-year-old man who accidentally inhaled his insulin syringe cap while swinging on his recliner with the cap perched in his mouth. He developed a dry irritating cough. On exam he had mild stridor in the upper airways and bilateral wheezing. The insulin cap was visualized by bronchoscopy in the right mainstem bronchus and retrieved with forceps.

Case 2 (Figure 2) is a 65-year-old man with chronic dysphagia and poor dentition who choked on a cashew. It took repeated coughing attempts to produce the cashew, but it was unclear whether the entire content was cleared. He then developed non-massive hemoptysis that persisted for 2 weeks. Thoracic CT showed ground glass opacities and an air fluid level in the right middle lobe. The foreign body was visualized in the right lower lobe bronchus as an endobronchial-filling defect. Bronchoscopy revealed a cashew piece in the right lower lobe bronchus. Forceps trials failed due to fragility of the foreign body, which was ultimately retrieved with scope suction.

Rigid bronchoscopy is the gold standard for diagnosis and management of tracheobronchial foreign body aspiration, but flexible bronchoscopy is another accepted method that is also more comfortable for the patient (1). Virtual bronchoscopy is a noninvasive procedure that can assist with localizing the foreign body and may have a role to play in follow-up assessment of airway patency (2). Pneumonia and atelectasis are common complications. Less common complications include bronchiectasis, bronchostenosis, hemoptysis, tracheal perforation, pneumomediastinum, and even cardiopulmonary arrest (3). Tracheal foreign bodies pose more danger than bronchial foreign bodies; in such cases the foreign body should be pushed to distal airways, crumbled if it is organic, and then extracted (1).

Khushboo Goel, MD¹, Huthayfa Ateeli, MBBS², Joshua Dill, DO2, Dena L’Heureux MD³

¹Department of Internal Medicine, University of Arizona, Tucson, AZ, USA

²Department of Internal Medicine, Division of Pulmonary, Critical Care, Sleep, and Allergy Medicine, University of Arizona, Tucson, AZ, USA

³Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Southern Arizona VA Health Care System, Tucson, AZ, USA

References

1. Altunas B, Aydin Y, Eroglu A. Foreign bodies in trachea: a 25 year experience. Eurasian J Med. 2016;48(2):119-123. [CrossRef] [PubMed]
2. Kshatriya RM, Khara NV, Paliwal RP, Patel SN. Role of virtual and flexible bronchoscopy in the management of a case of unnoticed foreign body aspiration presented as a nonresolving pneumonia in an adult female. Lung India. 2016; 33(4):420-423. [CrossRef] [PubMed]
3. Altunas B, Aydin Y, Eroğlu A. Complications of tracheobronchial foreign bodies. Turk J Med Sci. 2016;46(3):785-800. [CrossRef] [PubMed]

Cite as: Goel K, Ateeli H, Dill J, L’Heureux D. Medical image of the week: tracheobronchial foreign body aspiration. Southwest J Pulm Crit Care. 2016;13(4):184-5. doi: http://dx.doi.org/10.13175/swjpcc092-16 PDF

Medical Image of the Week: Right Middle Lobe Syndrome

Figure 1. Panel A: PA chest x-ray showing calcified mediastinal lymphadenopathy. Panel B:  Lateral view showing a triangle of increased density between the minor fissure and the lower half of the major fissure seen on the lateral view (blue arrow) .

Figure 2. Image from the thoracic CT scan in lung windows showing calcified mediastinal lymph notes (green arrows).

A 73 year-old woman, a lifetime non-smoker, presented to the pulmonary clinic with chronic dyspnea on exertion and cough. Physical exam was unremarkable and pulmonary function testing showed normal spirometry. A chest radiograph revealed calcified mediastinal adenopathy and increased density in the right middle lobe region (Figure 1).  A computed tomography scan of the chest revealed significant narrowing of the right middle lobe bronchus with partial atelectasis and prominent calcified mediastinal lymphadenopathy (Figure 2).  Bronchoscopy showed no endobronchial lesions but there was evidence of extrinsic compression surrounding the right middle lobe orifice.  An endobronchial biopsy revealed noncaseating granulomas. Bronchoscopy cultures and cytology were negative and this was presumed to be from a previous infection with histoplasmosis given the patient’s long-term residence in an endemic area. Given chronic narrowing of right middle lobe bronchus with persistent atelectasis of the right middle lobe, the patient was diagnosed with right middle lobe syndrome.  She was started on combination therapy with a long-acting beta agonist and inhaled corticosteroid with complete resolution of her symptoms.

Right middle lobe syndrome (RMLS) is defined as recurrent or chronic atelectasis of the right middle lobe.  Although more commonly described in children, it is becoming more prevalent in adults with a predilection for women.  There are two distinct types of pathophysiology- obstructive and non-obstructive.  Obstructive pathophysiology is defined when there is an endobronchial lesion or extrinsic compression of the middle lobe bronchus by lymphadenopathy (as in our case) or a tumor.  Non-obstructive pathophysiology occurs when there is recurrent infection or inflammation leading to bronchiectasis and scarring.  Certain anatomical characteristics, including the acute take-off angle of the right middle lobe bronchus create poor conditions for drainage and collateral ventilation (1).

Symptoms of RMLS include chronic or recurrent cough, dyspnea, wheezing and recurrent infections.  High resolution computed tomography of the chest is the gold standard for imaging, as this will show narrowing of the right middle lobe orifice along with etiologies of extrinsic compression (Figure 2).  Patients suspected of having RMLS warrant a bronchoscopy to evaluate for patency of right middle lobe bronchus, to exclude malignancy and for evaluation of infectious etiologies (1).  The treatment of RMLS includes bronchodilator therapy along with mucolytics, chest physiotherapy and antibiotics if bronchiectasis is problematic.  Lobectomy may be warranted if malignancy is diagnosed, aggressive medical management fails or hemoptysis occurs (2). 

Elaine A. Cristan, MD and Linda Snyder, MD

Department of Medicine

Division of Pulmonary, Critical Care, Sleep and Allergy Medicine

Banner University Medical Center

Tucson, AZ USA

References

1. Gudbjartsson T, Gudmundsson G. Middle lobe syndrome: a review of clinicopathological features, diagnosis and treatment. Respiration. 2012;84(1):80-6. [CrossRef] [PubMed]
2. Einarsson JT, Einarsson JG, Isaksson H, Gudbjartsson T, Gudmundsson G. Middle lobe syndrome: a nationwide study on clinicopathological features and surgical treatment. Clin Respir J. 2009 Apr;3(2):77-81. [CrossRef] [PubMed] 

Cite as: Cristan EA, Snyder L. Medical image of the week: right middle lobe syndrome. Southwest J Pulm Crit Care. 2016; May;12(5):199-200. doi: http://dx.doi.org/10.13175/swjpcc030-16 PDF 

Medical Image of the Week: Achalasia with Lung Abscess

Figure 1. CT coronal view showing a left lower lobe lung abscess measuring approximately 8 x 5 cm.

Figure 2. Barium swallow study showed dilated esophagus with tapering off at the lower esophageal sphincter junction, demonstrating the classic bird-beak like appearance.

Figure 3. Upper endoscopy showing diffuse whitish plaque suggestive of candidiasis likely due to chronic stasis of food.

An 80-year old woman with past medical history of high grade serous fallopian tube carcinoma presented with 2 months history of productive cough. This was associated with shortness of breath and subjective fever, chills and weight loss of 5 pounds over 2 months. She was treated with outpatient antibiotics without improvement of symptoms. Patient was afebrile on presentation, hemodynamically stable, and saturating at 99% on room air. Lung examinations revealed dullness on percussion of left lower lung field and reduced breath sounds on the same area.

Computed tomographic imaging revealed a large lung abscess on left lower lobe (Figure 1) and moderately dilated esophagus and fluid filled to the level of gastro-esophagus junction. Barium swallow study showed a classic bird-beak like appearance (Figure 2). There was no contrast that passed through the gastro-esophagus junction during the entire course of the barium study. Upper endoscopy was performed to rule out intraluminal pathology that may contribute to the obstruction which revealed a large amount of barium and retained food in the entire esophagus with diffuse whitish plaque suggestive of candidiasis and a benign appearing intrinsic mild stenosis at lower third of esophagus (Figure 3). Pneumatic dilation and botulinum toxin injection were performed and she was started on pantoprazole. She was also started on broad-spectrum antibiotics (vancomycin, cefepime, metronidazole) for the lung abscess. A chest tube was inserted under computed tomography (CT) guidance. Subsequently, cultures from the chest tube drainage grew Streptococcus intermedius. She was discharged to a skilled nursing facility with additional 3-weeks of ampicillin-sulbactam. Repeat imaging at 3-weeks showed improvement of the lung abscess.

Achalasia is a rare primary esophageal motor disorder, with incidence of approximately 1 in 100,000 people annually and prevalence of 10 in 100,000 (1). Common presentations of achalasia includes gradual dysphagia to solid and liquids, heartburn symptoms unrelieved by adequate proton pump inhibitor therapy and weight loss. Achalasia presenting with respiratory symptoms without dysphagia is rare as this disease entity is gradual and patient will normally present with different degrees of dysphagia or regurgitation of food. This case report is a good reminder that aspiration should be considered as a cause for pneumonia in the elderly. Our patient could have been aspirating for a period of time, leading to the development of a large lung abscess. Kikuchi et al. (2) demonstrated the high incidence of silent aspiration in the elderly population. A more detailed assessment by trained swallowing therapist may aid in detecting dysphagia.

Kai Rou Tey MD¹ and Naser Mahmoud MD²

¹Department of Internal Medicine University of Arizona College of Medicine- South Campus

²Department of Pulmonary, Critical Care, Allergy and Sleep, University of Arizona College of Medicine

Tucson, AZ USA

References

1. Francis DL, Katzka DA. Achalasia: update on the disease and its treatment. Gastroenterology. 2010 Aug;139(2):369-74. [CrossRef] [PubMed]
2. Kikuchi R, Watabe N, Konno T, Mishina N, Sekizawa K, Sasaki H. High incidence of silent aspiration in elderly patients with community-acquired pneumonia. Am J Respir Crit Care Med. 1994 Jul;150(1):251-3. [CrossRef] [PubMed]

Cite as: Tey KR, Mahmoud N. Medical image of the week: achalasia with lung abscess. Southwest J Pulm Crit Care. 2016 May;12(5):194-6. doi: http://dx.doi.org/10.13175/swjpcc025-16 PDF

Medical Image of the Week: Acute Amiodarone Pulmonary Toxicity

Figure 1. Chest X-ray showing diffuse interstitial markings, right upper lobe consolidation, small pleural effusions, thoracotomy wires and external leads.

Figure 2. Axial image of the thoracic CT scan showing increased interstitial markings, ground glass opacities and bilateral pleural effusions.

A 71 year old man with a medical history significant for chronic obstructive pulmonary disease, coronary artery disease with post-operative status coronary artery bypass grafting, heart failure with reduced ejection fraction (25%) and atrial fibrillation/flutter underwent an elective ablation of the tachyarrhythmia at another facility and was prescribed amiodarone post procedure. He started complaining of cough and dyspnea one day post procedure and was empirically treated with 2 weeks of broad spectrum antibiotics. He subsequently was transferred to our facility due to worsening symptoms. He also complained of nausea, anorexia with resultant weight loss since starting amiodarone, which was stopped 5 days prior to transfer. Infectious work up was negative.

On arrival to our facility, he was diagnosed with small sub-segmental pulmonary emboli, pulmonary edema and possible acute amiodarone toxicity. His was profoundly hypoxic requiring high flow nasal cannula or 100% non-rebreather mask at all times. His symptoms persisted despite antibiotics, diuresis, anticoagulation and heart rate control. Steroid therapy was then initiated for acute amiodarone toxicity. Although he reported some improvement in symptoms 2-3 days after initiation of steroids, his oxygen requirement did not improve. Unfortunately he suffered a cardiac arrest on day 10 of admission and did not survive.

Amiodarone is a class B anti-arrhythmic used to treat multiple supraventricular and ventricular tachyarrhythmias. Its adverse effects are usually dose and duration dependent. Amiodarone pulmonary toxicity (APT) has been shown to correlate with total cumulative dose; however acute reactions to amiodarone toxicity have previously been reported. Men are at increased risk for APT, and this risk increases with age and those with pre-existing lung conditions. Diagnosis of APT is predominantly a diagnosis of exclusion; however laboratory tests may show leukocytosis with neutrophil predominance (as in our patient) and imaging may provide a clue for diagnosis. Chest x-ray reveals patchy or diffuse infiltrates, which may have predominance in the upper lobes, particularly the right upper lobe (as in our patient). A thoracic CT scan may show bilateral alveolar or interstitial infiltrates with higher attenuation, secondary to the iodine component of the drug. The current mainstay of treatment is discontinuation of the drug permanently along with steroid therapy typically, 40-60 mg of prednisone a day for an extended period of time.  

Konstantin Mazursky DO¹, Bhupinder Natt MD², Laura Meinke MD^1,2

¹Department of Internal Medicine.

²Division of Pulmonary, Critical Care, Allergy and Sleep

Banner-University Medical Center

Tucson AZ

Reference

1. Wolkove N, Baltzan M. Amiodarone pulmonary toxicity. Can Respir J. 2009;16(2):43-8. [PubMed] 

Cite as: Mazursky K, Natt B, Meinke L. Medical image of the week: acute amiodarone pulmonary toxicity. Southwest J Pulm Crit Care. 2015;11(4):189-90. doi: http://dx.doi.org/10.13175/swjpcc099-15 PDF

Medical Image of the Week: Healthcare-associated Pneumonia Secondary to Aspiration

Figure 1. Panel A: Axial computed-tomography image demonstrating a foreign body within the right main-stem bronchus, with consolidation and volume loss of right lung. Panel B: Coronal view.

Figure 2. Panel A: bronchoscopy revealing an ingested foreign body in the right main-stem bronchus. Panel B: forceps retrieval yielded a large piece of broccoli.

A 57 year-old bedbound paraplegic man developed a worsening productive cough after being hospitalized for several days. He was brought to the radiology suite for a CT scan of the chest, revealing a soft tissue density within his right main-stem bronchus, with volume loss of his right lung (Figure 1). Bronchoscopy was performed, yielding a 2 cm piece of broccoli, successfully removed with forceps (Figure 2). Culture from the bronchial aspirate was positive for Pseudomonas aeruginosa. The patient’s respiratory status dramatically improved after removal of the foreign body and commencement of pathogen-directed antibiotics. This study illustrates a dramatic example of healthcare-associated pneumonia (HCAP) secondary to aspiration, as described by the American Thoracic Society / Infectious Diseases Society of America (1).

Lavi Nissim MD, Sam Alnajjar MD and Edward Vivio RT

Phoenix Baptist Hospital

2000 W. Bethany Home Road

Phoenix, AZ 85015

Reference

1. American Thoracic Society; Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med. 2005;171(4):388-416. [CrossRef] [PubMed]

Reference as: Nissim L, Alnajjar S, Vivio E. Medical image of the week: healthcare-associated pneumonia secondary to aspiration. Southwest J Pulm Crit Care. 2015;11(1):1-2. doi: http://dx.doi.org/10.13175/swjpcc065-15 PDF