November 2019 Imaging Case of the Month: A 56-Year-Old Woman with a Rash

Michael B. Gotway, MD

Department of Radiology

Mayo Clinic Arizona

Scottsdale, AZ USA

Clinical History: A 56-year-old post-menopausal woman with a remote history of asthma and asymptomatic uterine fibroids presented with a macular-papular rash over the upper chest, upper medial left forearm, and medial legs, without scaling that has intermittently recurred over the previous few years. The rash is unaccompanied by fever, chills, rigors, abdominal pain, cough, conjunctivitis, urethritis, or any other mucocutaneous lesions. The patient did not note any seasonal relationships or association with food, and the rash regresses promptly with H₁ or H₂-blocker therapy.

The patient’s past medical history was otherwise unremarkable. Her surgical history was positive only for a laparoscopic left inguinal hernia repair 7 years earlier. The patient indicated she was neither a smoker nor a drinker. Her medications included an as-needed albuterol inhaler, a steroid inhaler, a nasal steroid spray, a multivitamin, and a topical steroid.

The patient’s physical examination showed normal vital signs, although her pulse rate was 95 beats / minute. The physical examination was otherwise entirely within normal limits aside from her presenting complaint of rash; in particular, her lungs were clear to auscultation. 

About 2 weeks later, the patient began to complain of myalgias and some wheezing in addition to her rash, with some mild fatigue as well. She denied other complaints, such as coryza, cough, nasal drainage, ear pain, and neck pain or stiffness. At repeat physical examination, her lungs remained clear to auscultation; no wheezing was noted. A dermatology consult suggested that the rash was most consistent with atopic dermatitis, for which a topical steroid was prescribed.

Basic laboratory data showed a white blood cell count in the normal range, mild anemia (hemoglobin / hematocrit = 11.5 mg/dL / 34.7%), a normal platelet count, normal serum chemistries and renal function parameters, and normal liver function tests aside from a mildly elevated alkaline phosphatase level of 145  U/L147 (normal, 35 – 104 U/L). A C-reactive protein level was elevated at 38.5 mg/L (normal, ≤8 mg/L). The patient was referred for chest radiography (Figure 1).

Figure 1.  Frontal chest radiograph.

Which of the following statements regarding the chest radiograph is most accurate? (Click on the correct answer to be directed to the second of twelve pages)

1. The chest radiograph shows mediastinal and peribronchial lymph node enlargement
2. The chest radiograph shows bilateral consolidation
3. The chest radiograph shows cavitary lung disease
4. The chest radiograph shows findings suggesting increased pressure pulmonary edema
5. The chest radiograph shows numerous small nodules

Cite as: Gotway MB. November 2019 imaging case of the month: a 56-year-old woman with a rash. Southwest J Pulm Crit Care. 2019;19(5):127-43. doi: https://doi.org/10.13175/swjpcc065-19 PDF 

August 2013 Imaging Case of the Month

Michael B. Gotway, MD

Department of Radiology

Mayo Clinic Arizona

Scottsdale, AZ

Clinical History

A 60-year-old man presented with gradually worsening shortness of breath and dry cough over the previous six months, unresponsive to presumptive antibiotic therapy with levofloxacin first, followed by azithromycin. Frontal chest radiography (Figure 1) was performed. 

Figure 1. Frontal chest radiography.

Which of the following statements regarding the chest radiograph is most accurate?

1. The chest radiograph shows basal predominant fibrotic lung disease
2. The chest radiograph shows large lung volumes with cystic change
3. The chest radiograph shows multifocal bronchiectasis
4. The chest radiograph shows multiple nodules
5. The chest radiograph shows upper lobe peripheral consolidation and reticulation

Reference as: Gotway MB. August 2013 imaging case of the month. Southwest J Pulm Crit Care. 2013;7(2):75-83. doi: http://dx.doi.org/10.13175/swjpcc102-13  PDF

April 2012 Imaging Case of the Month

Michael B. Gotway, MD

Associate Editor, Imaging

Clinical History: A 31-year-old previously healthy, immunocompetent, non-smoking female developed cough and was initially treated with broad spectrum antibiotics without improvement. Approximately 48 hours later, the patient presented to her physician with progressive shortness of breath and fever to 103°F. A chest radiograph was performed (Figure 1).

Figure 1: Frontal chest radiograph shows extensive bilateral pulmonary opacities predominantly in the lower lobes with preserved lung volumes, normal mediastinal width, and no definite pleural effusion.

The differential diagnostic considerations for the appearance on the chest radiograph include which of the following?

1. Hydrostatic pulmonary edema
2. Acute hypersensitivity pneumonitis
3. Community-acquired pneumonia
4. Opportunistic pulmonary infection
5. All of the above

Reference as: Gotway MB. April 2012 imaging case of the month. Southwest J Pulm Crit Care 2012;4:102-10. (Click here for a PDF version)