Medical Image of the Week: Sarcoidosis

Figure 1. The AP supine chest radiograph depicts bilateral hilar calcified lymphadenopathy with characteristic popcorn appearance of the lymph nodes (white arrows).  Incidentally noted are a tunneled dialysis catheter terminating in the right atrium and median sternotomy wires from a previous coronary artery bypass graft surgery.

We present a 58-year-old African American man with a complicated medical history including long-standing sarcoidosis that has caused him chronic, unrelenting pain for two decades.  He initially underwent placement of an intrathecal morphine pump, but recently began complaining of increasing pain.  Consequently, he was seen at our hospital for interrogation of his pain pump by the interventional radiologist, and was incidentally noted to have bilateral calcified hilar lymphadenopathy on fluoroscopic imaging.  A dedicated chest x-ray confirmed the abnormality, which was consistent with his known diagnosis of sarcoidosis.

Sarcoidosis is a complex disease process characterized by noncaseous granulomas that can affect various organ systems, with pulmonary involvement in up to 90% of cases (1).  Though sarcoidosis is a diagnosis of exclusion, clinicians should recognize that bilateral hilar lymphadenopathy is highly concerning for the underlying noncaseating granulomatous disease (2).  The most common pattern of lymphadenopathy is well-defined, bilateral, symmetric hilar and right paratracheal lymph node enlargement. Bilateral hilar lymph node enlargement, alone or in combination with mediastinal lymph node enlargement, occurs in an estimated 95% of patients affected with sarcoidosis (1). Although bilateral hilar adenopathy may be a feature of other disease processes including infections (especially fungal or mycobacterium) and malignancy (metastases or lymphoma), sarcoidosis is the most common cause of bilateral hilar lymphadenopathy in the absence of specific clinical features of these processes. The enlarged lymph nodes eventually calcify, and the chronicity of the disease process directly correlates to hilar lymphadenopathy calcification, occurring in up to 20% of patients after 10 years (3).  Of note are the popcorn like calcifications within perihilar lymph nodes silhouetting the normal vascular anatomy (Figure 1).

Amrit Hansra, MD and Unni Udayasankar, MD

Department of Medical Imaging

University of Arizona

Tucson, AZ

References

1. Criado E, Sánchez M, Ramírez J, Arguis P, de Caralt TM, Perea RJ, Xaubet A. Pulmonary sarcoidosis: typical and atypical manifestations at high-resolution CT with pathologic correlation. Radiographics. 2010;30(6):1567-86. [CrossRef] [PubMed]
2. Baughman RP, Culver DA, Judson MA. A concise review of pulmonary sarcoidosis. Am J Respir Crit Care Med. 2011;183(5):573-81. [CrossRef] [PubMed]
3. Miller BH, Rosado-de-Christenson ML, McAdams HP, Fishback NF. Thoracic sarcoidosis: radiologic-pathologic correlation. Radiographics. 1995;15(2):421-37. [CrossRef] [PubMed]

Cite as: Hansra A, Udayasankar U. Medical image of the week: sarcoidosis. Southwest J Pulm Crit Care. 2016;12(2):62-3. doi: http://dx.doi.org/10.13175/swjpcc003-16 PDF

Medical Image Of The Week: Westermark Sign

Figure 1. Chest x-ray showing decrease pulmonary vasculature on the right upper lobe (red circle, Westermark sign).

Figure 2. Coronal section of the CT angiogram showing occlusive thrombosis on the right pulmonary artery. 

A 71 year old man was evaluated in the Emergency Department for acute onset of dyspnea. On exam he was tachypneic, tachycardic and hypoxemic requiring 6 L/min of oxygen. He had recently underwent prostatectomy for prostate cancer. Past medical history was also significant for coronary artery disease treated with coronary bypass.

The chest x-ray (Figure 1) shows unilateral oligemia concerning for a pulmonary embolus and the CT angiogram of the chest (Figure 2) confirms the diagnosis.

While the chest radiograph is normal in the majority of pulmonary emboli, the ‘Westermark sign’ may be seen in up to 2% of the cases (1). It represents a focus of oligemia seen distal to a pulmonary embolism. The finding is a result of a combination of dilation of the pulmonary artery proximal to the thrombus and the collapse of the distal vasculature. 

Muna Omar MD¹, Tammer Elaini MD² and Bhupinder Natt MD¹

¹Division of Pulmonary, Allergy , Critical Care and Sleep Medicine

²Department of Internal Medicine

University of Arizona Medical Center

Tucson, AZ

Reference

1. Worsley DF, Alavi A, Aronchick JM, Chen JT, Greenspan RH, Ravin CE. Chest radiographic findings in patients with acute pulmonary embolism: observations from the PIOPED Study. Radiology. 1993;189(1):133-6. [CrossRef] [PubMed] 

Reference as: Omar M, Elaini T, Natt B. Medical image of the week: Westermark sign. Southwest J Pulm Crit Care. 2015;10(3):125-6. doi: http://dx.doi.org/10.13175/swjpcc015-15 PDF

March 2015 Imaging Case of the Month

Michael B. Gotway, MD

Department of Radiology

Mayo Clinic Arizona

Scottsdale, AZ

Clinical History: A 35-year-old man presented with a history of Von Hippel-Lindau syndrome, including prior right-sided renal cell carcinomas, cerebellar hemangioblastomas, and retinal hemangiomas. The patient’s renal malignancies were treated with laparoscopic radiofrequency ablations 6 and 8 years prior to presentation, and subsequently with percutaneous microwave ablations in the interim between 2008 and presentation. The latest percutaneous microwave ablation procedure (Figure 1) was performed to address two nodular enhancing foci in the posterior superior pole of the right kidney and one interpolar enhancing, septated lesion that were noted to have enlarged slightly on a recent MRI examination (Figure 2) of the abdomen compared with one year earlier.

 Figure 1. Percutaneous microwave of three right-sided renal lesions, 2 posterior-superior pole, the other lateral interpolar in location, shows two NeuWave microwave antennas inserted into suspicious lesions in the right kidney.

 

Figure 2. MRI of abdomen (A and B, axial steady-state free precession fat saturation images and, C and D, coronal subtraction contrast-enhanced images) shows three potentially solid, enhancing foci, two in the posterior and superior pole of the right kidney (arrowheads), and one in the lateral interpolar kidney, the latter with thick septations (arrow) that have shown slight enlargement from MR. performed one year previously.

A CT of the abdomen (Figure 3), performed 2 years earlier, is shown as a baseline comparison.

Figure 3.  Upper panel: selected image from the CT of the abdomen performed 2 years prior to presentation shows enlargement of the bilateral kidneys with numerous, bilateral renal cystic lesions. No pleural or lung base abnormality is evident. Lower panel: movie of CT scan performed 2 years prior to presentation.

Several days following the percutaneous microwave ablation procedure, the patient complained of right-sided chest pain, and frontal chest radiography was performed (Figure 4). 

Figure 4. Frontal and lateral chest radiography performed several days following the right-sided percutaneous microwave ablation procedure.

Which of the following statements regarding the chest radiograph is most accurate? (Click on the correct answer to proceed to the second of seven panels)

1. The frontal chest radiograph shows a large right pleural effusion
2. The frontal chest radiograph shows diffuse lung opacities suggesting diffuse alveolar damage
3. The frontal chest radiograph shows mediastinal widening
4. The frontal chest radiograph shows pneumomediastinum
5. The frontal chest radiograph shows pneumothorax 

Reference as: Gotway MB. March 2015 imaging case of the month. Southwest J Pulm Crit Care. 2015;10(3):112-24. doi: http://dx.doi.org/10.13175/swjpcc031-15 PDF

October 2014 Imaging Case of the Month

Sameh Sakla, M.D.

Clinton Jokerst, M.D.

Department of Medical Imaging

University of Arizona Medical Center

Tucson, AZ

A 53-year-old man presents with fatigue and dyspnea on exertion. An admission chest radiograph (Figure 1) was obtained.

Figure 1. Admission chest radiograph.

What is the best term or phrase used to describe the salient radiographic abnormality?

1. Diffuse thick-walled cavitary lesions
2. Interstitial and alveolar pulmonary edema with effusions
3. Miliary nodules
4. Patchy consolidation
5. Tension pneumothorax

Reference as: Sakla S, Jokerst C. October 2014 imaging case of the month. Southwest J Pulm Crit Care. 2014;9(4):214-8. doi: http://dx.doi.org/10.13175/swjpcc126-14 PDF 

September 2014 Imaging Case of the Month

Michael B. Gotway, MD

Department of Radiology

Mayo Clinic Arizona

Scottsdale, AZ

Clinical History: A 57-year-old non-smoking woman presented to her physician as an outpatient with complaints of worsening cough, fever, chills, and shortness of breath. The patient’s past medical history includes systemic lupus erythematosus diagnosed 18 years earlier, for which the patient has been variably treated with corticosteroids, hydroxychloroquine, and azathioprine. Additional past medical and surgical history includes migraines, mood disorder, diabetes mellitus treated with metformin, hysterectomy for endometriosis, and iron-deficient anemia. The patient was also diagnosed with small lymphocytic lymphoma 3 years earlier following a right breast biopsy when an abnormal opacity was discovered incidentally at routine screening breast imaging. She has not been treated for this neoplasm as no B symptoms have been reported.

Frontal and lateral chest radiography (Figure 1) was performed.

Figure 1. Panel A: Initial frontal chest x-ray. Panel B: Initial lateral chest x-ray.

Which of the following statements regarding the chest radiograph is most accurate? (Click on the correct answer to proceed to the next panel)

1. The chest radiograph shows asymmetric pulmonary vascularity
2. The chest radiograph shows bilateral linear and reticular opacities and diminished lung volumes suggesting fibrotic lung disease
3. The chest radiograph shows linear and curvilinear opacities suggesting cystic lung disease
4. The chest radiograph shows mild streaky central opacities, possibly reflecting airway thickening
5. The chest radiograph shows numerous small nodules

Reference as: Gotway MB. September 2014 imaging case of the month. Southwest J Pulm Crit Care. 2014;9(3):161-76. doi: http://dx.doi.org/10.13175/swjpcc117-14 PDF 

Medical Image of the Week: Pneumomediastinum

Figure 1.  Chest x-ray (CXR) shows subtle evidence of pneumomediastinum with air outlining left cardiac border and trachea (arrows).

 

Figure 2. Chest computerized tomography (CT) showing pneumomediastinum (Panel A) extending into lower neck (Panel B) without evidence of pneumothorax.

A 65 year old man presented with mild increase in shortness of breath. He had a past medical history of diabetes mellitus, hypertension, and severe malnutrition with percutaneous endoscopic gastrostomy (PEG) placement after a colectomy and end ileostomy for sigmoid volvulus. CXR (Figure 1) suggested a pneumomediastinum with subsequent chest CT (Figure 2) confirming moderate sized pneumomediastinum. He had a chronic cough from chronic obstructive pulmonary disease (COPD) as well as aspiration and chest CT also demonstrated emphysema with small blebs. He denied any significant chest pain. He was followed conservatively with imaging and discharged in stable condition.

Pneumomediastinum can be caused by trauma, esophageal rupture after vomiting (Boerhaave’s syndrome) and can be a spontaneous event if no obvious precipitating cause is identified (1). Valsalva maneuvers such as cough, sneeze, vomiting and childbirth, can all cause pneumomediastinum. Risk factors include asthma, COPD, interstitial lung disease and inhalational recreational drug use. Hamman's sign (a crunching sound in time with the heartbeat) can occasionally be heard.  More commonly, subcutaneous emphysema is felt on exam (crepitus). Complications can include single or bilateral pneumothorax, tension pneumothorax and pleural effusion. CXR often does not identify mediastinal air and CT imaging is highly sensitive and confirmatory. Conservative management is recommended with close clinical follow up for possible complications.

Rene Franco, Jr MD, Mohammad Dalabih MD, Janet Campion MD

University of Arizona Medical Center, Tucson AZ

Reference

1. Newcomb AE, Clarke CP. Spontaneous Pneumomediastinum. Chest. 2005;128:3298-3302. [CrossRef] [PubMed] 

Reference as: Franco R Jr, Dalabih M, Campion J. Medical image of the week: pneumomediastinum. Southwest J Pulm Crit Care. 2014:8(1):46-7. doi: http://dx.doi.org/10.13175/swjpcc160-13 PDF

October 2013 Imaging Case of the Month

Michael B. Gotway, MD

Department of Radiology

Mayo Clinic Arizona

Scottsdale, AZ 

Clinical History

A 67-year-old man with a history of hypertension and chronic lymphocytic leukemia (CLL), the latter diagnosed 10 years earlier, in remission until recently, presented with complaints of weight loss, not eating much, lethargy, and shortness of breath. His CLL had recurred and he was treated with rituximab, and bendamustine (a nitrogen mustard alkylating agent) and intravenous immunoglobulin. Frontal chest radiography (Figure 1) was performed.

Figure 1. Initial chest radiograph.

Which of the following statements regarding the chest radiograph is most accurate?

1. The chest radiograph shows basal predominant linear opacities suggesting fibrosis
2. The chest radiograph shows large lung volumes with cystic change
3. The chest radiograph shows multifocal ground-glass opacity and cavitary consolidation
4. The chest radiograph shows multifocal ground-glass opacity and consolidation associated with linear and reticular abnormalities
5. The chest radiograph shows multiple nodules

Reference as: Gotway MB. October 2013 imaging case of the month. Southwest J Pulm Crit Care. 2013;7(4):223-31. doi: http://dx.doi.org/10.13175/swjpcc133-13 PDF