Imaging
Those who care for patients with pulmonary, critical care or sleep disorders rely heavily on chest radiology and pathology to determine diagnoses. The Southwest Journal of Pulmonary, Critical Care & Sleep publishes case-based articles with characteristic chest imaging and related pathology.
The editor of this section will oversee and coordinate the publication of a core of the most important chest imaging topics. In doing so, they encourage the submission of unsolicited manuscripts. It cannot be overemphasized that both radiologic and pathologic images must be of excellent quality. As a rule, 600 DPI is sufficient for radiographic and pathologic images. Taking pictures of plain chest radiographs and CT scans with a digital camera is strongly discouraged. The figures should be cited in the text and numbered consecutively. The stain used for pathology specimens and magnification should be mentioned in the figure legend. Those who care for patients with pulmonary, critical care or sleep disorders rely heavily on chest radiology and pathology to determine diagnoses. The Southwest Journal of Pulmonary, Critical Care & Sleep publishes case-based articles with characteristic chest imaging and related pathology. The editor of this section will oversee and coordinate the publication of a core of the most important chest imaging topics. In doing so, they encourage the submission of unsolicited manuscripts. It cannot be overemphasized that both radiologic and pathologic images must be of excellent quality. As a rule, 600 DPI is sufficient for radiographic and pathologic images. Taking pictures of plain chest radiographs and CT scans with a digital camera is strongly discouraged. The figures should be cited in the text and numbered consecutively. The stain used for pathology specimens and magnification should be mentioned in the figure legend.
Medical Image of the Month: Giant Bulla
Figure 1. A chest radiograph demonstrates marked oligemia of the left lung with displacement of the cardiomediastinal silhouette to the right. Subtle, linear lung parenchymal markings are noted in the base of the left lung hinting at extensive bullous disease and not a pneumothorax (red arrows).
Figure 2. A CT of the chest with contrast in lung windows demonstrates a giant bulla centered in the left upper lobe. Adjacent bullous disease is also present.
Clinical Background: A 49-year-old gentleman with an extensive smoking history who was transferred from an outside hospital for higher level of care for management of his acute hypoxemic respiratory failure. His outside chest radiograph (Figure 1) demonstrated marked oligemia of the left lung with displacement of the cardiomediastinal silhouette to the right. Subtle linear parenchymal markings are noted in the lower lobe suggesting bullous disease. There is extensive airspace disease of the right lung. A CT of the chest (Figure 2) demonstrated extensive bullous disease with a giant bulla noted in the left upper lobe. The patient was transferred to the MICU for further management of his hypoxemic respiratory failure. A CT surgery consult was obtained, and he was deemed not to be a surgical candidate given his tenuous clinical status.
Discussion: A bulla is defined as an air-containing space measuring greater than 1 cm in diameter and surrounded by a thin wall which is less than 1 mm thick. Bulla are usually located in a subpleural location and can be seen with emphysema - both paraseptal and centrilobular types. A giant bulla is defined as a bulla occupying at least 30% of a hemithorax. In this case, the patient had a giant bulla centered in the left upper lobe.
Giant bullae typically develop because of long-term cigarette smoking, which is the most likely cause in this case. Bullous lung disease has also been associated with HIV infection and intravenous use of methadone, methylphenidate, or talc-containing drugs.
In asymptomatic patients, smoking cessation is recommended to prevent further progression. In dyspneic patients with COPD, medical therapy with bronchodilators, inhaled corticosteroids, supplemental oxygen, and pulmonary rehab are recommended. In patients who have dyspnea despite medical optimization or who have issues with a spontaneous, secondary pneumothorax, a bullectomy may be beneficial. Contraindications to a bullectomy include ongoing cigarette smoking, significant comorbid disease, poorly-defined bullae on chest imaging, pulmonary hypertension, and other comorbid conditions that make surgery high risk.
Leslie Littlefield MD and Mohammed Fayed MD
UCSF Fresno
Fresno, CA USA
References
- Rosado-de-Christenson M, Abbott GF. Diagnostic Chest Imaging. 2nd edition. Canada: Amirsys; 2012; Section 1, p 15.
- Diaz PT, Clanton TL, Pacht ER. Emphysema-like pulmonary disease associated with human immunodeficiency virus infection. Ann Intern Med. 1992 Jan 15;116(2):124-8. [CrossRef] [PubMed]
- Palla A, Desideri M, Rossi G, Bardi G, Mazzantini D, Mussi A, Giuntini C. Elective surgery for giant bullous emphysema: a 5-year clinical and functional follow-up. Chest. 2005 Oct;128(4):2043-50. [CrossRef] [PubMed]
Cite as: Littlefield L, Fayed M. Medical image of the month: giant bulla. Southwest J Pulm Crit Care. 2019;19(4):125-6. doi: https://doi.org/10.13175/swjpcc040-19 PDF